TY - JOUR
T1 - Frailty Index as a Predictor of Mortality in Middle-Aged and Older People
T2 - A Prospective Analysis of Chilean Adults
AU - on behalf of ELHOC Research Consortium
AU - Diaz-Toro, Felipe
AU - Nazar, Gabriela
AU - Troncoso, Claudia
AU - Concha-Cisternas, Yeny
AU - Leiva-Ordoñez, Ana Maria
AU - Martinez-Sanguinetti, Maria Adela
AU - Parra-Soto, Solange
AU - Lasserre-Laso, Nicole
AU - Cigarroa, Igor
AU - Mardones, Lorena
AU - Vásquez-Gómez, Jaime
AU - Petermann-Rocha, Fanny
AU - Diaz-Martinez, Ximena
AU - Celis-Morales, Carlos
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/1
Y1 - 2023/1
N2 - We aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged ≥ 35 from the Chilean National Health Survey 2009–2010. Mortality was determined through linkage with the Chilean Civil Registry and Identification. A 36-item frailty index (FI) was used to assess the frailty status. Associations between frailty status and all-cause mortality were assessed using Kaplan–Meier and Cox proportional hazard models adjusted for sociodemographic and lifestyle factors. A non-linear association was investigated using penalized cubic splines fitted in the Cox models. During an 8.9 median follow-up (interquartile range of 8.6–9.0), 308 individuals died (11.5%). Lower survival rates were observed in frail individuals compared to pre-frail and robust people (log-rank < 0.001). Compared with robust individuals, frail people had a higher mortality risk (HR: 2.35 [95% CI: 1.57 to 3.51]). Frail middle-aged individuals had a higher risk of dying independently of major risk factors.
AB - We aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged ≥ 35 from the Chilean National Health Survey 2009–2010. Mortality was determined through linkage with the Chilean Civil Registry and Identification. A 36-item frailty index (FI) was used to assess the frailty status. Associations between frailty status and all-cause mortality were assessed using Kaplan–Meier and Cox proportional hazard models adjusted for sociodemographic and lifestyle factors. A non-linear association was investigated using penalized cubic splines fitted in the Cox models. During an 8.9 median follow-up (interquartile range of 8.6–9.0), 308 individuals died (11.5%). Lower survival rates were observed in frail individuals compared to pre-frail and robust people (log-rank < 0.001). Compared with robust individuals, frail people had a higher mortality risk (HR: 2.35 [95% CI: 1.57 to 3.51]). Frail middle-aged individuals had a higher risk of dying independently of major risk factors.
KW - Chile
KW - frailty
KW - middle-aged
KW - mortality
UR - http://www.scopus.com/inward/record.url?scp=85146810645&partnerID=8YFLogxK
U2 - 10.3390/ijerph20021195
DO - 10.3390/ijerph20021195
M3 - Article
C2 - 36673951
AN - SCOPUS:85146810645
SN - 1661-7827
VL - 20
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 2
M1 - 1195
ER -
