Focal palmoplantar and gingival keratosis – A rare genodermatoses: Case report

Roberto Gerber-Mora, Martín Jajam-Maturana, Alejandra Fernández-Moraga, Rene Martinez-Flores

Research output: Contribution to journalArticlepeer-review


Focal palmoplantar and gingival keratosis syndrome is a rare dominant inherited disease with an early onset in life. Clinically, the condition is characterized by pressure related thickening of the epidermis of the palms and soles, usually accompanied by pain and different levels of skin involvement and thickness between patients. Recently, we observed a 38-year-old woman with multiple non-removable, painless white plaques of variable size and thickness on the attached gingiva and a white plaque widespread across the hard palate. By further questioning, the patient comments that she has thick yellowish focal plaques in both soles of her feet. Histopathological analysis revealed a hyperplastic and hyperorthokeratinized stratified squamous epithelium with basal hyperplasia. The spinous, granular and stratum corneum showed dispersed basophilic keratohyalin granules. At higher magnification, the keratinocytes contained paranuclear bodies, seen as round eosinophilic condensation that indented the nuclei. Based on these findings the final diagnosis was rendered as focal palmoplantar and gingival keratosis.

Original languageEnglish
Pages (from-to)e1096-e1099
JournalJournal of Clinical and Experimental Dentistry
Issue number11
Publication statusPublished - Nov 2020


  • dyskeratosis
  • Genodermatoses
  • gingiva
  • white plaque

ASJC Scopus subject areas

  • General Dentistry


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