Fertility regulation in nursing women. II. Comparative performance of progesterone implants versus placebo and copper T

H. B. Croxatto, S. Díaz, O. Peralta, G. Juez, M. E. Casado, A. M. Salvatierra, E. Durán

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

A clinical study was designed to test whether sustained administration of progesterone to nursing mothers could prolong lactation and delay the postpartum recovery of fertility. The hormone was administered by subdermal implantation of six pellets that each contained 100 mg of progesterone. This treatment was administered to 84 fully nursing women on day 30 post partum. Control groups were composed of 130 fully nursing women who received an injectable placebo, and by 125 fully nursing women who received a TCu 200 intrauterine contraceptive device. An exacting list of requirements for admission to and continuation in the study was applied to all groups. No pregnancies occurred in the progesterone-treated group from the second to the sixth postpartum month. This period coincided with the period of elevated plasma progesterone attributable to hormone released from the implants. The cumulative probability of pregnancy in the placebo group was 10.2 per 100 women at the sixth month. Treatment with progesterone did not change the duration of lactation or the rate of child growth, and no adverse effects were recorded. These results warrant further investigation of the use of progesterone as an alternative method to prevent conception in nursing women.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalAmerican Journal of Obstetrics and Gynecology
Volume144
Issue number2
Publication statusPublished - 15 Sep 1982

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

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