Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells

Verónica A. Burzio; Claudio Villota; Jaime Villegas; Eduardo Landerer; Enrique Boccardo; Luisa L. Villa; Ronny Martínez; Constanza Lopez; Fancy Gaete; Viviana Toro; Ximena Rodriguez; Luis O. Burzio

doi:10.1073/pnas.0903086106

Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells

Verónica A. Burzio, Claudio Villota, Jaime Villegas, Eduardo Landerer, Enrique Boccardo, Luisa L. Villa, Ronny Martínez, Constanza Lopez, Fancy Gaete, Viviana Toro, Ximena Rodriguez, Luis O. Burzio

Life Sciences School

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Abstract

We reported the presence in human cells of a noncoding mitochondrial RNA that contains an inverted repeat (IR) of 815 nucleotides (nt) covalently linked to the 5' end of the mitochondrial 16S RNA (16S mtrRNA). The transcript contains a stem-loop structure and is expressed in human proliferating cells but not in resting cells. Here, we demonstrate that, in addition to this transcript, normal human proliferating cells in culture express 2 antisense mitochondrial transcripts. These transcripts also contain stem-loop structures but strikingly they are down-regulated in tumor cell lines and tumor cells present in 17 different tumor types. The differential expression of these transcripts distinguishes normal from tumor cells and might contribute a unique vision on cancer biology and diagnostics.

Original language	English
Pages (from-to)	9430-9434
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	106
Issue number	23
DOIs	https://doi.org/10.1073/pnas.0903086106
Publication status	Published - 9 Jun 2009

Keywords

Differential expression in cancer
RNAs with stem-loop structures

ASJC Scopus subject areas

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10.1073/pnas.0903086106

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Burzio, V. A., Villota, C., Villegas, J., Landerer, E., Boccardo, E., Villa, L. L., Martínez, R., Lopez, C., Gaete, F., Toro, V., Rodriguez, X., & Burzio, L. O. (2009). Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 106(23), 9430-9434. https://doi.org/10.1073/pnas.0903086106

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title = "Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells",

abstract = "We reported the presence in human cells of a noncoding mitochondrial RNA that contains an inverted repeat (IR) of 815 nucleotides (nt) covalently linked to the 5' end of the mitochondrial 16S RNA (16S mtrRNA). The transcript contains a stem-loop structure and is expressed in human proliferating cells but not in resting cells. Here, we demonstrate that, in addition to this transcript, normal human proliferating cells in culture express 2 antisense mitochondrial transcripts. These transcripts also contain stem-loop structures but strikingly they are down-regulated in tumor cell lines and tumor cells present in 17 different tumor types. The differential expression of these transcripts distinguishes normal from tumor cells and might contribute a unique vision on cancer biology and diagnostics.",

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doi = "10.1073/pnas.0903086106",

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Burzio, VA, Villota, C, Villegas, J, Landerer, E, Boccardo, E, Villa, LL, Martínez, R, Lopez, C, Gaete, F, Toro, V, Rodriguez, X & Burzio, LO 2009, 'Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 23, pp. 9430-9434. https://doi.org/10.1073/pnas.0903086106

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T1 - Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells

AU - Burzio, Verónica A.

AU - Villota, Claudio

AU - Villegas, Jaime

AU - Landerer, Eduardo

AU - Boccardo, Enrique

AU - Villa, Luisa L.

AU - Martínez, Ronny

AU - Lopez, Constanza

AU - Gaete, Fancy

AU - Toro, Viviana

AU - Rodriguez, Ximena

AU - Burzio, Luis O.

PY - 2009/6/9

Y1 - 2009/6/9

N2 - We reported the presence in human cells of a noncoding mitochondrial RNA that contains an inverted repeat (IR) of 815 nucleotides (nt) covalently linked to the 5' end of the mitochondrial 16S RNA (16S mtrRNA). The transcript contains a stem-loop structure and is expressed in human proliferating cells but not in resting cells. Here, we demonstrate that, in addition to this transcript, normal human proliferating cells in culture express 2 antisense mitochondrial transcripts. These transcripts also contain stem-loop structures but strikingly they are down-regulated in tumor cell lines and tumor cells present in 17 different tumor types. The differential expression of these transcripts distinguishes normal from tumor cells and might contribute a unique vision on cancer biology and diagnostics.

AB - We reported the presence in human cells of a noncoding mitochondrial RNA that contains an inverted repeat (IR) of 815 nucleotides (nt) covalently linked to the 5' end of the mitochondrial 16S RNA (16S mtrRNA). The transcript contains a stem-loop structure and is expressed in human proliferating cells but not in resting cells. Here, we demonstrate that, in addition to this transcript, normal human proliferating cells in culture express 2 antisense mitochondrial transcripts. These transcripts also contain stem-loop structures but strikingly they are down-regulated in tumor cell lines and tumor cells present in 17 different tumor types. The differential expression of these transcripts distinguishes normal from tumor cells and might contribute a unique vision on cancer biology and diagnostics.

KW - Differential expression in cancer

KW - RNAs with stem-loop structures

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DO - 10.1073/pnas.0903086106

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AN - SCOPUS:67249083965

SN - 0027-8424

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 23

ER -

Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells

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