Introduction: Rosacea is a chronic dermatosis associated with numerous immunoinflammatory conditions. Periodontitis is an inflammatory oral disease that affects the supporting tissues of the teeth and has been linked to psoriasis and atopic dermatitis. The aim of this study was to explore the association between rosacea and periodontitis. Methods: A case-control study was conducted on adults with rosacea attending the Dental Clinic of Universidad Andrés Bello. Controls consisted of healthy individuals matched 1:1 with cases based on age, sex, and smoking habit. Clinical and dermatological evaluations were conducted by a pre-calibrated dermatologist using teledermatology. Oral evaluations were performed by a periodontist using full-mouth periodontal charts. The diagnosis of periodontal disease was determined according to the Page & Eke classification for population-based studies. Relative risk was estimated using a Poisson linear regression model. Results: This study included 20 subjects with rosacea and 20 healthy controls, predominantly women. Subjects with rosacea showed a higher frequency and severity of periodontitis, as well as a higher frequency of dental brushing compared to controls (p > 0.05). A positive association was observed between rosacea and moderate to severe periodontitis (RR: 2.16 (1.03-4.55) and 2.6 (1.29-5.21), respectively), but not with mild periodontitis. Conclusions: Rosacea diagnosis was positively associated with moderate and severe periodontitis. Further studies are needed to confirm the exact relationship between both conditions and explore potential causal and confounding factors involved.
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