Experimental cardio-depressant effects of clonixin

D. Bustamante; M. Morales; T. Pelissier; H. Saavedra; H. F. Miranda; C. Paeile

doi:10.1016/0306-3623(89)90094-3

Experimental cardio-depressant effects of clonixin

D. Bustamante, M. Morales, T. Pelissier, H. Saavedra, H. F. Miranda, C. Paeile

Medicine School

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

1. 1. The cardiovascular effects of CLX were studied. 2. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)_max were reduced and duration increased. 4. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents.

Original language	English
Pages (from-to)	605-608
Number of pages	4
Journal	General Pharmacology
Volume	20
Issue number	5
DOIs	https://doi.org/10.1016/0306-3623(89)90094-3
Publication status	Published - 1989

ASJC Scopus subject areas

Pharmacology

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10.1016/0306-3623(89)90094-3

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title = "Experimental cardio-depressant effects of clonixin",

abstract = "1. 1. The cardiovascular effects of CLX were studied. 2. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)max were reduced and duration increased. 4. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents.",

author = "D. Bustamante and M. Morales and T. Pelissier and H. Saavedra and Miranda, {H. F.} and C. Paeile",

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doi = "10.1016/0306-3623(89)90094-3",

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T1 - Experimental cardio-depressant effects of clonixin

AU - Bustamante, D.

AU - Morales, M.

AU - Pelissier, T.

AU - Saavedra, H.

AU - Miranda, H. F.

AU - Paeile, C.

PY - 1989

Y1 - 1989

N2 - 1. 1. The cardiovascular effects of CLX were studied. 2. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)max were reduced and duration increased. 4. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents.

AB - 1. 1. The cardiovascular effects of CLX were studied. 2. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)max were reduced and duration increased. 4. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents.

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DO - 10.1016/0306-3623(89)90094-3

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AN - SCOPUS:0024430766

VL - 20

SP - 605

EP - 608

JO - Vascular Pharmacology

JF - Vascular Pharmacology

SN - 1537-1891

IS - 5

ER -

Experimental cardio-depressant effects of clonixin

Abstract

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