Experimental cardio-depressant effects of clonixin

D. Bustamante, M. Morales, T. Pelissier, H. Saavedra, H. F. Miranda, C. Paeile

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

1. 1. The cardiovascular effects of CLX were studied. 2. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)max were reduced and duration increased. 4. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents.

Original languageEnglish
Pages (from-to)605-608
Number of pages4
JournalGeneral Pharmacology
Volume20
Issue number5
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pharmacology

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