Evasión de la respuesta inmune por virus herpes simplex

Translated title of the contribution: Immune evasion by herpes simplex viruses

Angello R. Retamal-Díaz, Paula A. Suazo, Ignacio Garrido, Alexis M. Kalergis, Pablo A. González

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Herpes simplex viruses and humans have co-existed for tens of thousands of years. This long relationship has translated into the evolution and selection of viral determinants to evade the host immune response and reciprocally the evolution and selection of host immune components for limiting virus infection and damage. Currently there are no vaccines available to avoid infection with these viruses or therapies to cure them. Herpes simplex viruses are neurotropic and reside latently in neurons at the trigeminal and dorsal root ganglia, occasionally reactivating. Most viral recurrences are subclinical and thus, unnoticed. Here, we discuss the initial steps of infection by herpes simplex viruses and the molecular mechanisms they have developed to evade innate and adaptive immunity. A better understanding of the molecular mechanisms evolved by these viruses to evade host immunity should help us envision novel vaccine strategies and therapies that limit infection and dissemination.

Translated title of the contributionImmune evasion by herpes simplex viruses
Original languageSpanish
Pages (from-to)84-96
Number of pages13
JournalRevista Chilena de Infectologia
Volume32
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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