Evaluation of antibiotic dissemination into the environment and untreated animals, by analysis of oxytetracycline in poultry droppings and litter

Ekaterina Pokrant, Karina Yévenes, Lina Trincado, Gigliola Terraza, Nicolás Galarce, Aldo Maddaleno, Betty San Martín, Lisette Lapierre, Javiera Cornejo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Oxytetracycline (OTC) is widely used in broiler chickens. During and after treatment a fraction of OTC is excreted in its original form and as its epimer, 4-epi-OTC in droppings. To address the transfer of OTC into the environment, we evaluated the dissemination of OTC and 4-epiOTC from treated birds to the environment and sentinels, through the simultaneous analysis of broiler droppings and litter. Male broiler chickens were bred in controlled conditions. One group was treated by orogastric tube with 80 mg kg−1 of OTC and two groups received no treatment (sentinels). OTC+4-epi-OTC were analyzed and detected by a HPLC-MS/MS post the end of treatment. The highest concentrations of OTC+4-epi-OTC were detected in the droppings of treated birds 14days following the end of treatment (2244.66 µg kg−1), and one day following the end of treatment in the litter (22,741.68 µg kg−1). Traces of OTC+4-epi-OTC were detected in the sentinels’ droppings and litter (<12.2 µg kg−1). OTC+4-epi-OTC can be transferred from treated birds to the environment and to other untreated birds. The presence and persistence of OTC+4-epi-OTC in litter could contribute to the selection of resistant bacteria in the environment, increasing the potential hazard to public and animal health.

Original languageEnglish
Article number853
Pages (from-to)1-14
Number of pages14
JournalAnimals
Volume11
Issue number3
DOIs
Publication statusPublished - Mar 2021
Externally publishedYes

Keywords

  • 4-epi-Oxytetracycline
  • Antibiotic dissemination
  • Broiler chicken
  • HPLC-MS/MS
  • Oxytetracycline
  • Poultry droppings
  • Poultry litter
  • Sentinel birds

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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