Esporas de Clostridium difficile y su relevancia en la persistencia y transmisión de la infección

Translated title of the contribution: Clostridium difficile spores and its relevance in the persistence and transmission of the infection

Jonathan Barra-Carrasco, Cristian Hernández-Rocha, Patricio Ibáñez, Ana M. Guzmán-Durán, Manuel Álvarez-Lobos, Daniel Paredes-Sabja

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

C. difficile is an anaerobic spore former pathogen and the most important etiologic agent of nosocomial and community acquired antibiotics associated diarrheas. C. difficile infections (CDI) are responsible for an elevated rate of morbidity in developed and developing countries. Although the major virulence factors responsible for clinical symptoms of CDI are the two toxins TcdA and TcdB, C. difficile spores are the main vehicle of infection, persistence and transmission of CDI. Recent work has unrevealed unique properties of C. difficile spores that make them remarkable morphotypes of persistence and transmission in the host, including their resistance to antibiotics, the host immune response and disinfectants. The present review summarizes relevant aspects of C. difficile spore biology that have major implications from a clinical and medical perspective.

Translated title of the contributionClostridium difficile spores and its relevance in the persistence and transmission of the infection
Original languageSpanish
Pages (from-to)694-703
Number of pages10
JournalRevista Chilena de Infectologia
Volume31
Issue number6
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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