ESBL-producing escherichia coli carrying CTX-M genes circulating among livestock, dogs, and wild mammals in small-scale farms of central Chile

Julio A. Benavides, Marília Salgado-Caxito, Andrés Opazo-Capurro, Paulina González Muñoz, Ana Piñeiro, Macarena Otto Medina, Lina Rivas, Jose Munita, Javier Millán

Research output: Contribution to journalArticlepeer-review

Abstract

Antibiotic-resistant bacteria of critical importance for global health such as extendedspectrum beta-lactamases-producing (ESBL)-Escherichia coli have been detected in livestock, dogs, and wildlife worldwide. However, the dynamics of ESBL-E. coli between these animals remains poorly understood, particularly in small-scale farms of low and middle-income countries where contact between species can be frequent. We compared the prevalence of fecal carriage of ESBL-E. coli among 332 livestock (207 cows, 15 pigs, 60 horses, 40 sheep, 6 goats, 4 chickens), 82 dogs, and wildlife including 131 European rabbits, 30 rodents, and 12 Andean foxes sharing territory in peri-urban localities of central Chile. The prevalence was lower in livestock (3.0%) and wildlife (0.5%) compared to dogs (24%). Among 47 ESBL-E. coli isolates recovered, CTX-M-group 1 was the main ESBL genotype identified, followed by CTX-M-groups 2, 9, 8, and 25. ERIC-PCR showed no cluster of E. coli clones by either host species nor locality. To our knowledge, this is the first report of ESBL-E. coli among sheep, cattle, dogs, and rodents of Chile, confirming their fecal carriage among domestic and wild animals in small-scale farms. The high prevalence of ESBL-E. coli in dogs encourages further investigation on their role as potential reservoirs of this bacteria in agricultural settings.

Original languageEnglish
Article number510
JournalAntibiotics
Volume10
Issue number5
DOIs
Publication statusPublished - May 2021

Keywords

  • Antimicrobial resistance
  • bla
  • Chile
  • Domestic animals
  • E. coli
  • Extended-spectrum beta-lactamases
  • Wildlife

ASJC Scopus subject areas

  • Microbiology
  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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