Epigenetic regulation during 1,25-dihydroxyvitamin D3-dependent gene transcription

Daniel Moena, Esther Vargas, Martin Montecino

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Multiple evidence accumulated over the years, demonstrates that vitamin D-dependent physiological control in vertebrates occurs primarily through the regulation of target gene transcription. In addition, there has been an increasing appreciation of the role of the chromatin organization of the genome on the ability of the active form of vitamin D, 1,25(OH)2D3, and its specific receptor VDR to regulate gene expression. Chromatin structure in eukaryotic cells is principally modulated through epigenetic mechanisms including, but not limited to, a wide number of post-translational modifications of histone proteins and ATP-dependent chromatin remodelers, which are operative in different tissues during response to physiological cues. Hence, there is necessity to understand in depth the epigenetic control mechanisms that operate during 1,25(OH)2D3-dependent gene regulation. This chapter provides a general overview about epigenetic mechanisms functioning in mammalian cells and discusses how some of these mechanisms represent important components during transcriptional regulation of the model gene system CYP24A1 in response to 1,25(OH)2D3.

Original languageEnglish
Title of host publicationVitamins and Hormones
PublisherAcademic Press Inc.
Publication statusAccepted/In press - 2023

Publication series

NameVitamins and Hormones
ISSN (Print)0083-6729


  • 1,25-dihydroxyvitamin D
  • Epigenetic
  • Gene regulation
  • Transcription

ASJC Scopus subject areas

  • Physiology
  • Endocrinology


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