Environmental reprogramming of the expression of protein kinase CK2β subunit in fish

Marco Alvarez, Gudrun Kausel, Jaime Figueroa, María Inés Vera

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The dramatic segregation of the nucleolar components in winter-acclimatized carp is the most striking cellular-phenotypical feature observed during the seasonal adaptation of this fish toward the circannual changes in its habitat. Our studies also show that the carp habitat temperature and photoperiod winter conditions provoke a remarkable reduction of both rRNA transcription and the processing of their precursors. To gain knowledge on the mechanisms involved in the regulation of nucleolar activity during the seasonal adaptation process, we studied the behavior of some genes, specifically snoRNA U3 and protein kinase CK2. Consistent with the reduction in the synthesis and processing of pre-rRNA observed during the cold season, the level of CK2β expression decreases in winter when compared to that attained in summer. Similarly, in winter, liver and kidney cells contain lower levels of CK2β subunit protein compared to summer. CK2 is associated with or modifies different factors and enzymes involved in the nucleolar activity; therefore, its higher or lower content could be part of the molecular mechanisms underlying the nucleolar seasonal changes that occur during the compensatory acclimatization process.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume227
Issue number1-2
DOIs
Publication statusPublished - 2001

Keywords

  • Carp
  • Fish acclimatization
  • Nucleolus
  • Protein kinase CK2β subunit

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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