SignificancePannexin1 is a glycoprotein that has been shown to form functional plasma membrane channels and mediate many cellular signaling pathways. However, the formation and function of pannexin1-based intercellular cell-cell channels in mammalian cells and vertebrate tissue is a question of substantial debate. This work provides robust electrophysiological evidence to demonstrate that endogenously expressed human pannexin1 forms cell-cell channels and lays the groundwork for studying a potential new type of electrical synapses between many mammalian cell types that endogenously express pannexin1.
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|Publication status||Published - 3 May 2022|
- dye coupling
- dynamic asymmetry
- unitary events
ASJC Scopus subject areas