Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties

Nicolás Palacios-Prado, Paola A. Soto, Ximena López, Eun Ju Choi, Valeria Marquez-Miranda, Maximiliano Rojas, Yorley Duarte, Jinu Lee, Fernando D. González-Nilo, Juan C. Sáez

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

SignificancePannexin1 is a glycoprotein that has been shown to form functional plasma membrane channels and mediate many cellular signaling pathways. However, the formation and function of pannexin1-based intercellular cell-cell channels in mammalian cells and vertebrate tissue is a question of substantial debate. This work provides robust electrophysiological evidence to demonstrate that endogenously expressed human pannexin1 forms cell-cell channels and lays the groundwork for studying a potential new type of electrical synapses between many mammalian cell types that endogenously express pannexin1.

Original languageEnglish
Pages (from-to)e2202104119
JournalProceedings of the National Academy of Sciences of the United States of America
Volume119
Issue number18
DOIs
Publication statusPublished - 3 May 2022

Keywords

  • dye coupling
  • dynamic asymmetry
  • electrophysiology
  • permeability
  • unitary events

ASJC Scopus subject areas

  • General

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