Endocrinology: Luteinizing hormone pulsatile release and the length of lactational amenorrhoea

S. Díaz, H. Cárdenas, A. Zepeda, A. Brandeis, V. Schiappacasse, P. Miranda, M. Serón-ferré, H. B. Croxatto

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The pattern of luteinizing hormone (LH) pulsatile release and the mean concentrations of follicle-stimulating hormone, oestradiol and progesterone were studied in nursing and non-nursing women. Blood samples were drawn at 5 min intervals between 10: 00 and 14: 00 h and between 22: 00 and 02: 00 h at months 3-4, 5-6, 7-8 and 9-10 post-partum in nursing women and in the follicular phase in non-nursing women. In nursing women, mean LH concentrations at months 3-4 were significantly lower than in non-nursing cycling women only in the subgroup which subsequently experienced >6 months of lactational amenorrhoea, although all were fully nursing with a similar suckling frequency. LH pulses in plasma were found at all times in nursing women. There were no significant differences in the frequency (about four pulses every 4 h), amplitude or duration of LH pulses related to the duration of amenorrhoea, nor did these parameters vary significantly between amenorrhoeic or cycling nursing women and non-nursing women. Nursing amenorrhoeic women exhibited a normal frequency of LH pulse well in advance of the resumption of the first post-partum menses, suggesting that mechanisms other than the suppression of the gonadotrophin-releasing hormone pulse generator intervened in the inhibition of ovarian function during lactation.

Original languageEnglish
Pages (from-to)1957-1961
Number of pages5
JournalHuman Reproduction
Issue number8
Publication statusPublished - 1 Jan 1995


  • Breastfeeding
  • Lactational amenorrhoea
  • Luteinizing hormone pulses
  • Post-partum

ASJC Scopus subject areas

  • Reproductive Medicine
  • Rehabilitation
  • Obstetrics and Gynaecology


Dive into the research topics of 'Endocrinology: Luteinizing hormone pulsatile release and the length of lactational amenorrhoea'. Together they form a unique fingerprint.

Cite this