Endocrinology: Follicle stimulating hormone-granulosa cell axis involvement in the antifolliculotrophic effect of low dose mifepristone (RU486)

Horacio B. Croxatto, Ana M. Salvatierra, Blanca Fuentealba, Lino Leiva

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

This study was designed to assess the involvement of follicle stimulating hormone (FSH)-granulosa and luteinizing hormone (LH)-theca axes in the antifolliculotrophic effect of mifepristone. Plasma gonadotrophins, including plasma LH bioactivity and pulsatility, oestradiol, testosterone and inhibin concentrations, and follicular growth were monitored in volunteer women treated with placebo or mifepristone in two consecutive cycles. Mifepristone was given either as a single dose of 5 mg (n = 7) when the leading follicle had reached a diameter between 12 and 14 mm, or as a multiple dose of 5 mg/day for 3 days, beginning when the leading follicle had reached a diameter between 14 and 16 mm (n = 5) or between 6 and 11 mm (n = 5). Following the single dose of mifepristone, follicular growth and the accompanying increase in plasma oestradiol were arrested at 12 and 36 h respectively without changes in gonadotrophin or testosterone serum concentrations. The 3 day regimen arrested follicular growth and oestradiol rise and decreased plasma inhibin concentrations when follicles were larger than 12 mm at the onset of treatment. These results indicate that the antifolliculotrophic action of mifepristone is associated with a selective compromise of the FSH-granulosa axis of dominant follicles that have passed a critical stage of growth.

Original languageEnglish
Pages (from-to)1987-1991
Number of pages5
JournalHuman Reproduction
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 1995

Keywords

  • Follicular growth
  • Gonadotrophins
  • Inhibin
  • Mife-pristone

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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