Elucidating the Role of Innate and Adaptive Immune Responses in the Pathogenesis of Canine Chronic Inflammatory Enteropathy—A Search for Potential Biomarkers

Daniela Siel, Caroll J. Beltrán, Eduard Martínez, Macarena Pino, Nazla Vargas, Alexandra Salinas, Oliver Pérez, Ismael Pereira, Galia Ramírez-Toloza

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Canine chronic inflammatory enteropathy (CIE) is one of the most common chronic gastrointestinal diseases affecting dogs worldwide. Genetic and environmental factors, as well as intestinal microbiota and dysregulated host immune responses, participate in this multifactorial disease. Despite advances explaining the immunological and molecular mechanisms involved in CIE development, the exact pathogenesis is still unknown. This review compiles the latest reports and advances that describe the main molecular and cellular mechanisms of both the innate and adaptive immune responses involved in canine CIE pathogenesis. Future studies should focus research on the characterization of the immunopathogenesis of canine CIE in order to advance the establishment of biomarkers and molecular targets of diagnostic, prognostic, or therapeutic utility.

Original languageEnglish
Article number1645
JournalAnimals
Volume12
Issue number13
DOIs
Publication statusPublished - 1 Jul 2022

Keywords

  • adaptive immune response
  • canine chronic inflammatory enteropathy
  • inflammatory bowel disease
  • innate immune response
  • microbiota

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Fingerprint

Dive into the research topics of 'Elucidating the Role of Innate and Adaptive Immune Responses in the Pathogenesis of Canine Chronic Inflammatory Enteropathy—A Search for Potential Biomarkers'. Together they form a unique fingerprint.

Cite this