Effects of progressive resistance training on cognition and igf-1 levels in elder women who live in areas with high air pollution

Edgardo Molina-Sotomayor, Humberto Castillo-Quezada, Cristian Martínez-Salazar, Marcelo González-Orb, Alexis Espinoza-Salinas, Jose Antonio Gonzalez-Jurado

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The aim of this study was to determine the effects of a muscular strength programme on the levels of insulin-like growth factor-1 (IGF-1) and cognitive status in elder women with mild cognitive impairment who lived in areas of high air pollution. A total of 157 women participated in the study, distributed in four groups: Active/Clean (AC n = 38) and Active/Pollution (AP n = 37), who carried out a progressive resistance training programme for 24 months, and Sedentary/Clean (SC n = 40) and Sedentary/Pollution (SP n = 42). Maximum strength in the upper and lower limbs (1RM), cognition (Mini-Mental Scale Examination (MMSE)) and blood IGF-1 were evaluated. At the beginning of the intervention, there were no differences between the groups in the assessed variables. The active groups which carried out the resistance training programme (AC and AP), registered better results in IGF-1 than the sedentary groups. These differences were statistically significant in AC vs. SC (p < 0.01) and AP vs. SC (p < 0.05). Regarding MMSE, group AC registered the highest score increases (+8.2%) (significantly better than the other groups), while group SP worsened (−7%) significantly compared to the other three groups. In conclusion, resistance training had a positive effect on IGF-1, while sedentary behaviour and air pollution had a negative effect on cognitive status.

Original languageEnglish
Article number6203
Pages (from-to)1-17
Number of pages17
JournalInternational Journal of Environmental Research and Public Health
Issue number17
Publication statusPublished - 1 Sept 2020


  • Cognitive impairment
  • Exercise
  • Physical activity
  • Sedentarism
  • Strength muscular environmental health

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'Effects of progressive resistance training on cognition and igf-1 levels in elder women who live in areas with high air pollution'. Together they form a unique fingerprint.

Cite this