EFFECTS OF OXYPERTINE ON THE ISOLATED VAS DEFERENS OF THE RAT

H. MIRANDA

doi:10.1111/j.1476-5381.1978.tb07755.x

EFFECTS OF OXYPERTINE ON THE ISOLATED VAS DEFERENS OF THE RAT

H. MIRANDA

Medicine School

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The isolated vas deferens of the rat was used to examine the peripheral action of oxypertine, a psychotropic‐anxiolytic drug. Oxypertine (4.4 × 10⁻¹⁰m to 2.6 × 10⁻⁵m) antagonized competitively the effects of noradrenaline (pA₂ = 7.2), 5‐hydroxytryptamine (pA₂ = 8.6) and dopamine (pA₂ = 9.8). Oxypertine (8.8 × 10 ⁻⁹m to 2.6 × 10⁻⁵m) antagonized the effects of low concentrations of acetylcholine and enhanced the contractions elicited by high concentrations of acetylcholine. The contractions evoked by transmural stimulation of the vas deferens were reduced by oxypertine. Oxypertine failed to antagonize the responses to potassium chloride. These findings are compared with the effects of other antidepressant drugs. 1978 British Pharmacological Society

Original language	English
Pages (from-to)	515-518
Number of pages	4
Journal	British Journal of Pharmacology
Volume	62
Issue number	4
DOIs	https://doi.org/10.1111/j.1476-5381.1978.tb07755.x
Publication status	Published - Apr 1978

ASJC Scopus subject areas

Pharmacology

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10.1111/j.1476-5381.1978.tb07755.x

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title = "EFFECTS OF OXYPERTINE ON THE ISOLATED VAS DEFERENS OF THE RAT",

abstract = "The isolated vas deferens of the rat was used to examine the peripheral action of oxypertine, a psychotropic‐anxiolytic drug. Oxypertine (4.4 × 10−10m to 2.6 × 10−5m) antagonized competitively the effects of noradrenaline (pA2 = 7.2), 5‐hydroxytryptamine (pA2 = 8.6) and dopamine (pA2 = 9.8). Oxypertine (8.8 × 10 −9m to 2.6 × 10−5m) antagonized the effects of low concentrations of acetylcholine and enhanced the contractions elicited by high concentrations of acetylcholine. The contractions evoked by transmural stimulation of the vas deferens were reduced by oxypertine. Oxypertine failed to antagonize the responses to potassium chloride. These findings are compared with the effects of other antidepressant drugs. 1978 British Pharmacological Society",

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AB - The isolated vas deferens of the rat was used to examine the peripheral action of oxypertine, a psychotropic‐anxiolytic drug. Oxypertine (4.4 × 10−10m to 2.6 × 10−5m) antagonized competitively the effects of noradrenaline (pA2 = 7.2), 5‐hydroxytryptamine (pA2 = 8.6) and dopamine (pA2 = 9.8). Oxypertine (8.8 × 10 −9m to 2.6 × 10−5m) antagonized the effects of low concentrations of acetylcholine and enhanced the contractions elicited by high concentrations of acetylcholine. The contractions evoked by transmural stimulation of the vas deferens were reduced by oxypertine. Oxypertine failed to antagonize the responses to potassium chloride. These findings are compared with the effects of other antidepressant drugs. 1978 British Pharmacological Society

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EFFECTS OF OXYPERTINE ON THE ISOLATED VAS DEFERENS OF THE RAT

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