Effects of clonixin, a non-steroidal analgesic, on the neurotransmission of the vas deferens of the rat

1. 1. The effect of C1X on the responses to TNS, ACh and NE in the isolated rat vas deferens was studied. 2. 2. C1X produced a significant reduction of muscular twitch induced by TNS. 3. 3. The M₁-ACh response was significantly increased by this non-steroidal analgesic. 4. 4. The M₂-ACh response was not changed by pre-treatment with C1X. 5. 5. The α₁-NE response was not altered by C1X. 6. 6. The α₂-NE response was potentiated by pre-treatment with C1X. 7. 7. The findings suggest that C1X beside its ability to block the release of NE, has some common pharmacological properties, close to those of a "calcium modulator".