1. 1. The effect of C1X on the responses to TNS, ACh and NE in the isolated rat vas deferens was studied. 2. 2. C1X produced a significant reduction of muscular twitch induced by TNS. 3. 3. The M1-ACh response was significantly increased by this non-steroidal analgesic. 4. 4. The M2-ACh response was not changed by pre-treatment with C1X. 5. 5. The α1-NE response was not altered by C1X. 6. 6. The α2-NE response was potentiated by pre-treatment with C1X. 7. 7. The findings suggest that C1X beside its ability to block the release of NE, has some common pharmacological properties, close to those of a "calcium modulator".
|Number of pages||4|
|Publication status||Published - 1988|
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