Effect of oestradiol delivered from a perioviducal device on ovum transport in mice

J. Zenteno, C. Silva, H. Cardenas, H. B. Croxatto

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Silastic devices impregnated with oestradiol and blank devices were placed around both oviducts and around skeletal muscle bundles in the forelegs to attain local and systematic delivery, respectively. Another group of mice received an oestradiol-impregnated device around one oviduct and a blank device in the contralateral oviduct. Implantation of blank devices around the oviducts and in the forelegs did not alter ovum transport. Devices impregnated with oestradiol placed around both oviducts produced a dose-dependent delay of ovum transport, which was more pronounced than the effect of devices located in the forelegs. Oviducts receiving an oestradiol-loaded device had a larger retention of ova than did the contralateral oviducts receiving a blank device. These results demonstrate a direct action of oestradiol upon the oviduct to delay ovum transport in the mouse.

Original languageEnglish
Pages (from-to)545-548
Number of pages4
JournalJournal of Reproduction and Fertility
Issue number2
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Physiology
  • Embryology
  • Molecular Biology
  • Obstetrics and Gynaecology
  • Developmental Biology


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