Efecto del β-glucano: De avena sobre el índice glicémico y carga glicémica de un suplemento nutricional edulcorado con sucralosa en adultos sanos: Un ensayo clínico aleatorizado

Translated title of the contribution: Effect of oat β-glucan on glycemic index and glycemic load of a nutritional supplement sweetened with sucralose in healthy adults: A randomized clinical trial

Lissé Chiquinquirá Angarita Dávila, Diana Rojas Gómez, José López-Miranda, Karla Parra, María Uzcátegui, Daniel Aparicio, Virginia Céspedes, Robys González, Rendy Chaparro, Mabel Garrido, María Cristina Escobar, Paula Carrasco, Samuel Durán, Michelle Angarita, Nadia Reina, Sandra Wilches-Duran, Modesto Graterol-Rivas, José Chacón, Marco Cerda, Julio Contreras-VelasquezValmore Bermúdez

Research output: Contribution to journalArticle

Abstract

The hypoglycemic properties of oat β-glucan is of interest for the food industry and clinical area, for potencial health benefits by reducing glycemic response, serum low-density lipoprotein cholesterol, and glycemic index of meals. There are specific nutritional supplements for diabetics sweetened with sucralose whose glycemic index and glycemic load has not been established. Effect of oat β-glucan on glycemic index and glycemic load of a nutritional supplement sweetened with sucralose in healthy adults was determined in 13 healthy subjects (6 men and 7 women) old that consumed randomly 4 meals of 50 g of carbohydrates each in different days: a nutritional supplement for diabetics (FN), the nutritional supplement with β-glucan incorporated (FN-β) and two reference food, glucose solution (SG) and white bread (PB). Fasting and postprandial glycemia was measured at times 15, 30, 45, 60, 90 and 120 min. The area under the glycemia curve was lower for both formulas (FN) 12697±993, (FN-β) 11584 ±1171 than for reference products (SG) 13900±1245, y (PB) 13267 ± 1557. The values of glycemic index (GI) (FN) 67, 02 ± 5,69 and glycemic load were intermediate and more lower for the supplement with β-glucan incorporated (FN -β) 59, 8 ± 6,2, with no difference of insulin concentration. Suggesting that the addition of oat-derived β-glucan reduces the rate of intestinal absorption of glucose. This effect should be studied in diabetic.

Translated title of the contributionEffect of oat β-glucan on glycemic index and glycemic load of a nutritional supplement sweetened with sucralose in healthy adults: A randomized clinical trial
Original languageSpanish
Pages (from-to)77-85
Number of pages9
JournalArchivos Venezolanos de Farmacologia y Terapeutica
Volume35
Issue number4
Publication statusPublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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  • Cite this

    Dávila, L. C. A., Gómez, D. R., López-Miranda, J., Parra, K., Uzcátegui, M., Aparicio, D., Céspedes, V., González, R., Chaparro, R., Garrido, M., Escobar, M. C., Carrasco, P., Durán, S., Angarita, M., Reina, N., Wilches-Duran, S., Graterol-Rivas, M., Chacón, J., Cerda, M., ... Bermúdez, V. (2016). Efecto del β-glucano: De avena sobre el índice glicémico y carga glicémica de un suplemento nutricional edulcorado con sucralosa en adultos sanos: Un ensayo clínico aleatorizado. Archivos Venezolanos de Farmacologia y Terapeutica, 35(4), 77-85.