Early bunyavirus-host cell interactions

Amelina Albornoz, Anja B. Hoffmann, Pierre Yves Lozach, Nicole D. Tischler

Research output: Contribution to journalReview articlepeer-review

42 Citations (Scopus)

Abstract

The Bunyaviridae is the largest family of RNA viruses, with over 350 members worldwide. Several of these viruses cause severe diseases in livestock and humans. With an increasing number and frequency of outbreaks, bunyaviruses represent a growing threat to public health and agricultural productivity globally. Yet, the receptors, cellular factors and endocytic pathways used by these emerging pathogens to infect cells remain largely uncharacterized. The focus of this review is on the early steps of bunyavirus infection, from virus binding to penetration from endosomes. We address current knowledge and advances for members from each genus in the Bunyaviridae family regarding virus receptors, uptake, intracellular trafficking and fusion.

Original languageEnglish
JournalViruses
Volume8
Issue number5
DOIs
Publication statusPublished - 21 May 2016

Keywords

  • Bunyavirus
  • Cell entry
  • Endocytosis
  • Hantavirus
  • RNA virus
  • Tospovirus
  • Virus membrane fusion
  • Virus receptor

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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