Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia

Vladimir Vacic, Shane McCarthy, Dheeraj Malhotra, Fiona Murray, Hsun Hua Chou, Aine Peoples, Vladimir Makarov, Seungtai Yoon, Abhishek Bhandari, Roser Corominas, Lilia M. Iakoucheva, Olga Krastoshevsky, Verena Krause, Verãnica Larach-Walters, David K. Welsh, David Craig, John R. Kelsoe, Elliot S. Gershon, Suzanne M. Leal, Marie Dell AquilaDerek W. Morris, Michael Gill, Aiden Corvin, Paul A. Insel, Jon McClellan, Mary Claire King, Maria Karayiorgou, Deborah L. Levy, Lynn E. Delisi, Jonathan Sebat

Research output: Contribution to journalArticlepeer-review

261 Citations (Scopus)

Abstract

Rare copy number variants (CNVs) have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large (>500-kilobase) CNVs at several loci, including microdeletions at 1q21.1 (ref. 2), 3q29 (ref. 3), 15q13.3 (ref. 2) and 22q11.2 (ref. 4) and microduplication at 16p11.2 (ref. 5). However, these CNVs collectively account for a small fraction (2-4%) of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 (0.35%) patients versus 2 of 7,431 (0.03%) controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs.

Original languageEnglish
Pages (from-to)499-503
Number of pages5
JournalNature
Volume471
Issue number7339
DOIs
Publication statusPublished - 24 Mar 2011

ASJC Scopus subject areas

  • General

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