Drug and gut microbe relationships: Moving beyond antibiotics

Shreyas V. Kumbhare, Inti Pedroso, Juan A. Ugalde, Valeria Márquez-Miranda, Ranjan Sinha, Daniel E. Almonacid

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Our understanding of drug-microbe relationships has evolved from viewing microbes as mere drug producers to a dynamic, modifiable system where they can serve as drugs or targets of precision pharmacology. This review highlights recent findings on the gut microbiome, particularly focusing on four aspects of research: (i) drugs for bugs, covering recent strategies for targeting gut pathogens; (ii) bugs as drugs, including probiotics; (iii) drugs from bugs, including postbiotics; and (iv) bugs and drugs, discussing additional types of drug–microbe interactions. This review provides a perspective on future translational research, including efficient companion diagnostics in pharmaceutical interventions.

Original languageEnglish
Article number103797
JournalDrug Discovery Today
Issue number11
Publication statusPublished - Nov 2023


  • antimicrobial peptides (AMPs)
  • drug discovery
  • fecal microbiota transplantation (FMT)
  • live biotherapeutics
  • microbial pharmacogenomics
  • microbiome
  • multiomics integration
  • phage therapy
  • probiotics and prebiotics
  • therapeutic targets

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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