DPP9 Comes of Age: Highly Selective Inhibitors Promise New Therapeutic Opportunities

Verónica A. Jiménez

doi:10.1021/acs.jmedchem.3c01631

DPP9 Comes of Age: Highly Selective Inhibitors Promise New Therapeutic Opportunities

Research output: Contribution to journal › Review article › peer-review

Abstract

Dipeptidyl peptidase-like protein 9 (DPP9) is emerging as a promising drug target for the treatment of hematological diseases. Two novel DPP9 inhibitors with nanomolar affinity and unprecedented selectivity to DPP9 over DPP8 have been discovered, paving the way for future progress in DPP9-mediated treatments.

Original language	English
Pages (from-to)	12715-12716
Number of pages	2
Journal	Journal of Medicinal Chemistry
Volume	66
Issue number	18
DOIs	https://doi.org/10.1021/acs.jmedchem.3c01631
Publication status	Published - 28 Sept 2023

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/acs.jmedchem.3c01631

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title = "DPP9 Comes of Age: Highly Selective Inhibitors Promise New Therapeutic Opportunities",

abstract = "Dipeptidyl peptidase-like protein 9 (DPP9) is emerging as a promising drug target for the treatment of hematological diseases. Two novel DPP9 inhibitors with nanomolar affinity and unprecedented selectivity to DPP9 over DPP8 have been discovered, paving the way for future progress in DPP9-mediated treatments.",

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AB - Dipeptidyl peptidase-like protein 9 (DPP9) is emerging as a promising drug target for the treatment of hematological diseases. Two novel DPP9 inhibitors with nanomolar affinity and unprecedented selectivity to DPP9 over DPP8 have been discovered, paving the way for future progress in DPP9-mediated treatments.

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DPP9 Comes of Age: Highly Selective Inhibitors Promise New Therapeutic Opportunities

Abstract

ASJC Scopus subject areas

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