Differentially charged hollow core/shell lipid-polymer-lipid hybrid nanoparticles for small interfering rna delivery

Jinjun Shi; Zeyu Xiao; Alexander R. Votruba; Cristian Vilos; Omid C. Farokhzad

doi:10.1002/anie.201101554

Differentially charged hollow core/shell lipid-polymer-lipid hybrid nanoparticles for small interfering rna delivery

Jinjun Shi, Zeyu Xiao, Alexander R. Votruba, Cristian Vilos, Omid C. Farokhzad

Medicine School

Research output: Contribution to journal › Article › peer-review

157 Citations (Scopus)

Abstract

Speedy delivery: Biodegradable and biocompatible polymers and lipids form hybrid core/shell nanoparticles (see picture, left) that show promising in vitro and in vivo results for delivering siRNA. The unique lipid-polymer-lipid nanostructure is elucidated by electron and fluorescence microscopy (right) and provides the delivery system with distinct functional features.

Original language	English
Pages (from-to)	7027-7031
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	31
DOIs	https://doi.org/10.1002/anie.201101554
Publication status	Published - 25 Jul 2011

Keywords

lipids
nanoparticles
polymers
siRNA delivery

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201101554

Cite this

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abstract = "Speedy delivery: Biodegradable and biocompatible polymers and lipids form hybrid core/shell nanoparticles (see picture, left) that show promising in vitro and in vivo results for delivering siRNA. The unique lipid-polymer-lipid nanostructure is elucidated by electron and fluorescence microscopy (right) and provides the delivery system with distinct functional features.",

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AU - Vilos, Cristian

AU - Farokhzad, Omid C.

PY - 2011/7/25

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Differentially charged hollow core/shell lipid-polymer-lipid hybrid nanoparticles for small interfering rna delivery

Abstract

Keywords

ASJC Scopus subject areas

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