Differentially charged hollow core/shell lipid-polymer-lipid hybrid nanoparticles for small interfering rna delivery

Jinjun Shi, Zeyu Xiao, Alexander R. Votruba, Cristian Vilos, Omid C. Farokhzad

Research output: Contribution to journalArticlepeer-review

152 Citations (Scopus)

Abstract

Speedy delivery: Biodegradable and biocompatible polymers and lipids form hybrid core/shell nanoparticles (see picture, left) that show promising in vitro and in vivo results for delivering siRNA. The unique lipid-polymer-lipid nanostructure is elucidated by electron and fluorescence microscopy (right) and provides the delivery system with distinct functional features.

Original languageEnglish
Pages (from-to)7027-7031
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number31
DOIs
Publication statusPublished - 25 Jul 2011

Keywords

  • lipids
  • nanoparticles
  • polymers
  • siRNA delivery

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

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