Diferencia veno-arterial de dióxido de carbono como predictor de gasto cardiaco disminuido en modelo pediátrico experimental

Translated title of the contribution: Veno-arterial difference of carbondioxide as a predictor of low cardiac output in an experimental pediatric model

Franco Díaz, Alejandro Donoso, Cristóbal Carvajal, Tatiana Salomón, María Torres, Benjamín Erranz, Pablo Cruces

Research output: Contribution to journalArticle

Abstract

Background: Cardiac output (CO) measurement is not a standard of care for critically ill children, but it can be estimated by indirect methods such as veno-arterial pCO 2 difference (ΔVACO 2). Aim: To determine the correlation between CO and ΔVACO 2 and evaluate the usefulness of ΔVACO 2 in the diagnosis of low CO in an experimental pediatric model. Materials and Methods: Thirty piglets weighing 4.8 ± 0.35 kg were anesthetized and monitored with transpulmonary thermodilution. Lung injury was induced with tracheal instillation of Tween 20®. Serial measurements of central venous and arterial blood gases, as well as CO, were obtained at baseline, 1, 2 and 4 h after lung injury induction. Low cardiac output (LCO) was defined as CO lower than 2.5 L/min/m 2. Results: There was an inverse correlation between CO and ΔVACO 2 (r = -0.36, p < 0.01). ΔVACO 2 was 14 ± 8 mmHg in LCO state and 8 ± 6 mmHg when this condition was not present (p < 0.01). Area under the receiver operating characteristic (ROC) curves of ΔVACO 2 and LCO state was 0.78 (0.68-0.86). The best cut-point was 8.9 mmHg to determine LCO with a sensibility 0.78, specificity 0.7, positive predictive value 0.27 and negative predictive value 0.96. Conclusions: In this model there was an inverse correlation between ΔVACO 2 and CO. The best cutoff value to discard LCO was ΔVACO 2 of 8.9 mmHg, indicating that under this value the presence of LCO is very unlikely.

Translated title of the contributionVeno-arterial difference of carbondioxide as a predictor of low cardiac output in an experimental pediatric model
Original languageSpanish
Pages (from-to)39-44
Number of pages6
JournalRevista Medica de Chile
Volume140
Issue number1
DOIs
Publication statusPublished - Jan 2012

ASJC Scopus subject areas

  • Medicine(all)

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