Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model

Benjamín Erranz, Franco Díaz, Alejandro Donoso, Tatiana Salomón, Cristóbal Carvajal, María Fernanda Torres, Pablo Cruces

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background Preload dynamic tests, pulse pressure variation (PPV) and stroke volume variation (SVV) have emerged as powerful tools to predict response to fluid administration. The influence of factors other than preload in dynamic preload test is currently poorly understood in pediatrics. The aim of our study was to assess the effect of tidal volume (VT) on PPV and SVV in the context of normal and reduced lung compliance in a piglet model. Material and method Twenty large-white piglets (5.2 ± 0.4 kg) were anesthetized, paralyzed and monitored with pulse contour analysis. PPV and SVV were recorded during mechanical ventilation with a VT of 6 and 12 mL/kg (low and high VT, respectively), both before and after tracheal instillation of polysorbate 20. Results Before acute lung injury (ALI) induction, modifications of VT did not significantly change PPV and SVV readings. After ALI, PPV and SVV were significantly greater during ventilation with a high VT compared to a low VT (PPV increased from 8.9 ± 1.2 to 12.4 ± 1.1%, and SVV from 8.5 ± 1.0 to 12.7 ± 1.2%, both P < 0.01). Conclusions This study found that a high VT and reduced lung compliance due to ALI increase preload dynamic tests, with a greater influence of the latter. In subjects with ALI, lung compliance should be considered when interpreting the preload dynamic tests.

Original languageEnglish
Pages (from-to)404-409
Number of pages6
JournalRevista Chilena de Pediatria
Issue number6
Publication statusPublished - 1 Nov 2015


  • Acute lung injury
  • Hemodynamics
  • Mechanical ventilation
  • Pediatric
  • Preload

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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