Cysteine metabolism-related genes and bacterial resistance to potassium tellurite

Derie E. Fuentes; Eugenia L. Fuentes; Miguel E. Castro; José M. Pérez; Manuel A. Araya; Thomas G. Chasteen; Sergio E. Pichuantes; Claudio C. Vâsquez

doi:10.1128/JB.01252-07

Cysteine metabolism-related genes and bacterial resistance to potassium tellurite

Derie E. Fuentes, Eugenia L. Fuentes, Miguel E. Castro, José M. Pérez, Manuel A. Araya, Thomas G. Chasteen, Sergio E. Pichuantes, Claudio C. Vâsquez

Life Sciences School

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45 Citations (SciVal)

Abstract

Tellurite exerts a deleterious effect on a number of small molecules containing sulfur moieties that have a recognized role in cellular oxidative stress. Because cysteine is involved in the biosynthesis of glutathione and other sulfur-containing compounds, we investigated the expression of Geobacillus stearothermophilus V cysteine-related genes cob A, cysK, and iscS and Escherichia coli cysteine regulon genes under conditions that included the addition of K₂TeO₃ to the culture medium. Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium.

Original language	English
Pages (from-to)	8953-8960
Number of pages	8
Journal	Journal of Bacteriology
Volume	189
Issue number	24
DOIs	https://doi.org/10.1128/JB.01252-07
Publication status	Published - Dec 2007

ASJC Scopus subject areas

Microbiology
Molecular Biology

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abstract = "Tellurite exerts a deleterious effect on a number of small molecules containing sulfur moieties that have a recognized role in cellular oxidative stress. Because cysteine is involved in the biosynthesis of glutathione and other sulfur-containing compounds, we investigated the expression of Geobacillus stearothermophilus V cysteine-related genes cob A, cysK, and iscS and Escherichia coli cysteine regulon genes under conditions that included the addition of K2TeO3 to the culture medium. Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium.",

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AU - Fuentes, Derie E.

AU - Fuentes, Eugenia L.

AU - Castro, Miguel E.

AU - Pérez, José M.

AU - Araya, Manuel A.

AU - Chasteen, Thomas G.

AU - Pichuantes, Sergio E.

AU - Vâsquez, Claudio C.

PY - 2007/12

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N2 - Tellurite exerts a deleterious effect on a number of small molecules containing sulfur moieties that have a recognized role in cellular oxidative stress. Because cysteine is involved in the biosynthesis of glutathione and other sulfur-containing compounds, we investigated the expression of Geobacillus stearothermophilus V cysteine-related genes cob A, cysK, and iscS and Escherichia coli cysteine regulon genes under conditions that included the addition of K2TeO3 to the culture medium. Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium.

AB - Tellurite exerts a deleterious effect on a number of small molecules containing sulfur moieties that have a recognized role in cellular oxidative stress. Because cysteine is involved in the biosynthesis of glutathione and other sulfur-containing compounds, we investigated the expression of Geobacillus stearothermophilus V cysteine-related genes cob A, cysK, and iscS and Escherichia coli cysteine regulon genes under conditions that included the addition of K2TeO3 to the culture medium. Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium.

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Cysteine metabolism-related genes and bacterial resistance to potassium tellurite

Abstract

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