Cysteine metabolism-related genes and bacterial resistance to potassium tellurite

Derie E. Fuentes, Eugenia L. Fuentes, Miguel E. Castro, José M. Pérez, Manuel A. Araya, Thomas G. Chasteen, Sergio E. Pichuantes, Claudio C. Vâsquez

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Tellurite exerts a deleterious effect on a number of small molecules containing sulfur moieties that have a recognized role in cellular oxidative stress. Because cysteine is involved in the biosynthesis of glutathione and other sulfur-containing compounds, we investigated the expression of Geobacillus stearothermophilus V cysteine-related genes cob A, cysK, and iscS and Escherichia coli cysteine regulon genes under conditions that included the addition of K2TeO3 to the culture medium. Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium.

Original languageEnglish
Pages (from-to)8953-8960
Number of pages8
JournalJournal of Bacteriology
Volume189
Issue number24
DOIs
Publication statusPublished - Dec 2007

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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