Contribution of autophagy to antiviral immunity

Emma Rey-Jurado, Claudia A. Riedel, Pablo A. González, Susan M. Bueno, Alexis M. Kalergis

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)

Abstract

Although identified in the 1960's, interest in autophagy has significantly increased in the past decade with notable research efforts oriented at understanding as to how this multi-protein complex operates and is regulated. Autophagy is commonly defined as a "self-eating" process evolved by eukaryotic cells to recycle senescent organelles and expired proteins, which is significantly increased during cellular stress responses. In addition, autophagy can also play important roles during human diseases, such as cancer, neurodegenerative and autoimmune disorders. Furthermore, novel findings suggest that autophagy contributes to the host defense against microbial infections. In this article, we review the role of macroautophagy in antiviral immune responses and discuss molecular mechanisms evolved by viral pathogens to evade this process. A role for autophagy as an effector mechanism used both, by innate and adaptive immunity is also discussed.

Original languageEnglish
Pages (from-to)3461-3470
Number of pages10
JournalFEBS Letters
Volume589
Issue number22
DOIs
Publication statusPublished - 3 May 2015

Keywords

  • Adaptive immunity
  • Autophagy
  • Innate immunity
  • Macroautophagy
  • Virus

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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