Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel

Dale N. Robertson, Soledad Diaz, Francisco Alvarez-Sanchez, Pentti Holma, Daniel R. Mishell, Elsimar Coutinho, Vivian Brache, Horacio B. Croxatto, Anibal Paundes, Maria Lacarra, Margarita Pavez, Subir Roy, Ana Rita da Silva, Irving Sivin, Janet Stern

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A total of 189 women volunteered to accept subdermal implants for contraception. The implants were "covered rods", consisting of a core rod containing equal parts by weight of levonorgestrel and polydimethylsiloxane and sealed inside a thin-walled tube of Silastic tubing with medical adhesive. In one study 78 women used 4 3cm rods (study 07) and in the other 111 women used 6 3cm rods. In 5 years of use there were no pregnancies in either group. Terminations because of menstrual problems were twice as frequent among the 4-rod users than among users of the 6 rods. Menstrual pattern analysis is presented for the two rod regimens and compared with the previously reported patterns for the 6-capsule regimen (NORPLANTR). Long-term in vivo release rates are also presented.

Original languageEnglish
Pages (from-to)351-359
Number of pages9
JournalContraception
Volume31
Issue number4
DOIs
Publication statusPublished - Apr 1985

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Fingerprint

Dive into the research topics of 'Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel'. Together they form a unique fingerprint.

Cite this