Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel

Dale N. Robertson; Soledad Diaz; Francisco Alvarez-Sanchez; Pentti Holma; Daniel R. Mishell; Elsimar Coutinho; Vivian Brache; Horacio B. Croxatto; Anibal Paundes; Maria Lacarra; Margarita Pavez; Subir Roy; Ana Rita da Silva; Irving Sivin; Janet Stern

doi:10.1016/0010-7824(85)90003-4

Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel

Dale N. Robertson, Soledad Diaz, Francisco Alvarez-Sanchez, Pentti Holma, Daniel R. Mishell, Elsimar Coutinho, Vivian Brache, Horacio B. Croxatto, Anibal Paundes, Maria Lacarra, Margarita Pavez, Subir Roy, Ana Rita da Silva, Irving Sivin, Janet Stern

Medicine School

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A total of 189 women volunteered to accept subdermal implants for contraception. The implants were "covered rods", consisting of a core rod containing equal parts by weight of levonorgestrel and polydimethylsiloxane and sealed inside a thin-walled tube of Silastic tubing with medical adhesive. In one study 78 women used 4 3cm rods (study 07) and in the other 111 women used 6 3cm rods. In 5 years of use there were no pregnancies in either group. Terminations because of menstrual problems were twice as frequent among the 4-rod users than among users of the 6 rods. Menstrual pattern analysis is presented for the two rod regimens and compared with the previously reported patterns for the 6-capsule regimen (NORPLANT^R). Long-term in vivo release rates are also presented.

Original language	English
Pages (from-to)	351-359
Number of pages	9
Journal	Contraception
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/0010-7824(85)90003-4
Publication status	Published - Apr 1985

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynaecology

Access to Document

10.1016/0010-7824(85)90003-4

Cite this

Robertson, D. N., Diaz, S., Alvarez-Sanchez, F., Holma, P., Mishell, D. R., Coutinho, E., Brache, V., Croxatto, H. B., Paundes, A., Lacarra, M., Pavez, M., Roy, S., da Silva, A. R., Sivin, I., & Stern, J. (1985). Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel. Contraception, 31(4), 351-359. https://doi.org/10.1016/0010-7824(85)90003-4

@article{5fbe7a9966904645b28bf179976e4286,

title = "Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel",

abstract = "A total of 189 women volunteered to accept subdermal implants for contraception. The implants were {"}covered rods{"}, consisting of a core rod containing equal parts by weight of levonorgestrel and polydimethylsiloxane and sealed inside a thin-walled tube of Silastic tubing with medical adhesive. In one study 78 women used 4 3cm rods (study 07) and in the other 111 women used 6 3cm rods. In 5 years of use there were no pregnancies in either group. Terminations because of menstrual problems were twice as frequent among the 4-rod users than among users of the 6 rods. Menstrual pattern analysis is presented for the two rod regimens and compared with the previously reported patterns for the 6-capsule regimen (NORPLANTR). Long-term in vivo release rates are also presented.",

author = "Robertson, {Dale N.} and Soledad Diaz and Francisco Alvarez-Sanchez and Pentti Holma and Mishell, {Daniel R.} and Elsimar Coutinho and Vivian Brache and Croxatto, {Horacio B.} and Anibal Paundes and Maria Lacarra and Margarita Pavez and Subir Roy and {da Silva}, {Ana Rita} and Irving Sivin and Janet Stern",

note = "Funding Information: This work was undertaken as part of the contraceptive developmen? program sponsored and coordinated by the International Committee for Contraception Research of the Population Council, Inc., New York, New York. The financial support provided by the International Development Research Centre of Canada, the U.S. Agency for International Development (Grant AID/pha 11161, the Ford Foundation, the Rockefeller Foundation, the Mellon Foundation and the Geo. J. Hecht Fund is gratefully a c i:-. nowledged. The content doe: not necessarily reflect the policy{\textquoteright}of any of the funding sources",

year = "1985",

month = apr,

doi = "10.1016/0010-7824(85)90003-4",

language = "English",

volume = "31",

pages = "351--359",

journal = "Contraception",

issn = "0010-7824",

publisher = "Elsevier USA",

number = "4",

}

Robertson, DN, Diaz, S, Alvarez-Sanchez, F, Holma, P, Mishell, DR, Coutinho, E, Brache, V, Croxatto, HB, Paundes, A, Lacarra, M, Pavez, M, Roy, S, da Silva, AR, Sivin, I & Stern, J 1985, 'Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel', Contraception, vol. 31, no. 4, pp. 351-359. https://doi.org/10.1016/0010-7824(85)90003-4

TY - JOUR

T1 - Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel

AU - Robertson, Dale N.

AU - Diaz, Soledad

AU - Alvarez-Sanchez, Francisco

AU - Holma, Pentti

AU - Mishell, Daniel R.

AU - Coutinho, Elsimar

AU - Brache, Vivian

AU - Croxatto, Horacio B.

AU - Paundes, Anibal

AU - Lacarra, Maria

AU - Pavez, Margarita

AU - Roy, Subir

AU - da Silva, Ana Rita

AU - Sivin, Irving

AU - Stern, Janet

N1 - Funding Information: This work was undertaken as part of the contraceptive developmen? program sponsored and coordinated by the International Committee for Contraception Research of the Population Council, Inc., New York, New York. The financial support provided by the International Development Research Centre of Canada, the U.S. Agency for International Development (Grant AID/pha 11161, the Ford Foundation, the Rockefeller Foundation, the Mellon Foundation and the Geo. J. Hecht Fund is gratefully a c i:-. nowledged. The content doe: not necessarily reflect the policy’of any of the funding sources

PY - 1985/4

Y1 - 1985/4

N2 - A total of 189 women volunteered to accept subdermal implants for contraception. The implants were "covered rods", consisting of a core rod containing equal parts by weight of levonorgestrel and polydimethylsiloxane and sealed inside a thin-walled tube of Silastic tubing with medical adhesive. In one study 78 women used 4 3cm rods (study 07) and in the other 111 women used 6 3cm rods. In 5 years of use there were no pregnancies in either group. Terminations because of menstrual problems were twice as frequent among the 4-rod users than among users of the 6 rods. Menstrual pattern analysis is presented for the two rod regimens and compared with the previously reported patterns for the 6-capsule regimen (NORPLANTR). Long-term in vivo release rates are also presented.

AB - A total of 189 women volunteered to accept subdermal implants for contraception. The implants were "covered rods", consisting of a core rod containing equal parts by weight of levonorgestrel and polydimethylsiloxane and sealed inside a thin-walled tube of Silastic tubing with medical adhesive. In one study 78 women used 4 3cm rods (study 07) and in the other 111 women used 6 3cm rods. In 5 years of use there were no pregnancies in either group. Terminations because of menstrual problems were twice as frequent among the 4-rod users than among users of the 6 rods. Menstrual pattern analysis is presented for the two rod regimens and compared with the previously reported patterns for the 6-capsule regimen (NORPLANTR). Long-term in vivo release rates are also presented.

UR - http://www.scopus.com/inward/record.url?scp=0021794120&partnerID=8YFLogxK

U2 - 10.1016/0010-7824(85)90003-4

DO - 10.1016/0010-7824(85)90003-4

M3 - Article

C2 - 3924476

AN - SCOPUS:0021794120

SN - 0010-7824

VL - 31

SP - 351

EP - 359

JO - Contraception

JF - Contraception

IS - 4

ER -

Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this