Conformation analysis and biological activity of leptocarpin and leptocarpin acetate

R. Martinez, V. Kesternich, E. Gutierrez, H. Dolz, H. Mansilla

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


This paper deals with the conformational study in solution of leptocarpin, a germacranolide with the heliangolide structure isolated from Leptocarpha rivularis D.C. The results obtained agree with the single crystal X-ray diffraction studies. Leptocarpin and leptocarpin acetate show 50% inhibition of [35S]methionine uptake without affecting the (methyl-3H)thymidine and (5,6-3H)uridine incorporation, when assayed in HeLa cells.

Original languageEnglish
Pages (from-to)188-189
Number of pages2
JournalPlanta Medica
Issue number2
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Plant Science
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine


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