Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

Sebastian Fuentes-Retamal; Cristian Sandoval-Acuna; Liliana Peredo-Silva; Daniela Guzman-Rivera; Mario Pavani; Natalia Torrealba; Jaroslav Truksa; Vicente Castro-Castillo; Mabel Catalan; Ulrike Kemmerling; Felix A. Urra; Jorge Ferreira

doi:10.3390/cells9020407

Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

Sebastian Fuentes-Retamal, Cristian Sandoval-Acuna, Liliana Peredo-Silva, Daniela Guzman-Rivera, Mario Pavani, Natalia Torrealba, Jaroslav Truksa, Vicente Castro-Castillo, Mabel Catalan, Ulrike Kemmerling, Felix A. Urra, Jorge Ferreira

Medicine School

Research output: Other contribution › peer-review

27 Citations (Scopus)

Original language	English
Volume	9
DOIs	https://doi.org/10.3390/cells9020407
Publication status	Published - Feb 2020

Keywords

inhibition of the electron transport chain
inhibition of alpha-ketoglutarate dehydrogenase complex
mitochondrially targeted
decyl polyhydroxybenzoate triphenylphosphonium derivatives
doxycycline
mitochondrial ribosome inhibition

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/cells9020407

Cite this

Fuentes-Retamal, S., Sandoval-Acuna, C., Peredo-Silva, L., Guzman-Rivera, D., Pavani, M., Torrealba, N., Truksa, J., Castro-Castillo, V., Catalan, M., Kemmerling, U., Urra, F. A., & Ferreira, J. (2020, Feb). Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells. https://doi.org/10.3390/cells9020407

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title = "Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells",

keywords = "inhibition of the electron transport chain, inhibition of alpha-ketoglutarate dehydrogenase complex, mitochondrially targeted, decyl polyhydroxybenzoate triphenylphosphonium derivatives, doxycycline, mitochondrial ribosome inhibition",

author = "Sebastian Fuentes-Retamal and Cristian Sandoval-Acuna and Liliana Peredo-Silva and Daniela Guzman-Rivera and Mario Pavani and Natalia Torrealba and Jaroslav Truksa and Vicente Castro-Castillo and Mabel Catalan and Ulrike Kemmerling and Urra, {Felix A.} and Jorge Ferreira",

year = "2020",

month = feb,

doi = "10.3390/cells9020407",

language = "English",

volume = "9",

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Fuentes-Retamal, S, Sandoval-Acuna, C, Peredo-Silva, L, Guzman-Rivera, D, Pavani, M, Torrealba, N, Truksa, J, Castro-Castillo, V, Catalan, M, Kemmerling, U, Urra, FA & Ferreira, J 2020, Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells.. https://doi.org/10.3390/cells9020407

TY - GEN

T1 - Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

AU - Fuentes-Retamal, Sebastian

AU - Sandoval-Acuna, Cristian

AU - Peredo-Silva, Liliana

AU - Guzman-Rivera, Daniela

AU - Pavani, Mario

AU - Torrealba, Natalia

AU - Truksa, Jaroslav

AU - Castro-Castillo, Vicente

AU - Catalan, Mabel

AU - Kemmerling, Ulrike

AU - Urra, Felix A.

AU - Ferreira, Jorge

PY - 2020/2

Y1 - 2020/2

KW - inhibition of the electron transport chain

KW - inhibition of alpha-ketoglutarate dehydrogenase complex

KW - mitochondrially targeted

KW - decyl polyhydroxybenzoate triphenylphosphonium derivatives

KW - doxycycline

KW - mitochondrial ribosome inhibition

U2 - 10.3390/cells9020407

DO - 10.3390/cells9020407

M3 - Other contribution

VL - 9

ER -