Comparative genomics begins to unravel the ecophysiology of bioleaching

J. Valdés, J. P. Cárdenas, R. Quatrini, M. Esparza, H. Osorio, F. Duarte, C. Lefimil, R. Sepulveda, E. Jedlicki, D. S. Holmes

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A comparison of the metabolic potential of 20 bioleaching microorganisms and their close relatives from the Eubacteria and Archaea kingdoms permits the prediction of inter- and intra-species physiological interactions (ecophysiology) during spatial and temporal changes that are known to occur within industrial bioleaching heaps. Genome analysis has allowed preliminary models to be built for genes and pathways involved in key processes such as nitrogen and carbon cycling, sulfur and iron uptake and homeostasis, extra-cellular polysaccharide biosynthesis, heavy metal resistance and energy metabolism. This paper will focus on the diverse ways that bioleaching microorganisms obtain carbon from their environment with a particular emphasis on elucidating how these processes might be expected to vary over space and time during the lifetime of a bioleaching operation. It is anticipated that this knowledge will improve our understanding of fundamental biological processes in extremely acidic environments.

Original languageEnglish
Pages (from-to)471-476
Number of pages6
JournalHydrometallurgy
Volume104
Issue number3-4
DOIs
Publication statusPublished - 2010

Keywords

  • Acidithiobacillus
  • Bioinformatics
  • Bioleaching
  • Biomining
  • CO fixation
  • Comparative genomics
  • Ecophysiology
  • Metagenomic

ASJC Scopus subject areas

  • Metals and Alloys
  • Industrial and Manufacturing Engineering
  • Materials Chemistry

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    Valdés, J., Cárdenas, J. P., Quatrini, R., Esparza, M., Osorio, H., Duarte, F., Lefimil, C., Sepulveda, R., Jedlicki, E., & Holmes, D. S. (2010). Comparative genomics begins to unravel the ecophysiology of bioleaching. Hydrometallurgy, 104(3-4), 471-476. https://doi.org/10.1016/j.hydromet.2010.03.028