Clinical impact of osteosarcopenia on mortality, physical function and chronic inflammation: a 9-year follow up cohort study

Walter Sepúlveda Loyola, Jaqueline de Barros Morselli, Felipe Araya Quintanilla, Denilson Teixeira, Alejandro Alvarez Bustos, Mario Molari, Juan José Valenzuela Fuenzalida, Vanessa Suziane Probst

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Objective: This study aimed to determine the impact of osteosarcopenia on important clinical and functional outcomes in older adults. Methods: 242 community-dwelling older adults from the study on ageing and longevity (ELLO data from 2009 to 2018). Subjects underwent body composition analysis by dual energy X-ray absorptiometry and bioelectrical impedance, and assessments for aerobic capacity and muscle strength including the incremental shuttle walking test (ISWT), 6-minutes walking test (6MWT), handgrip strength (HGS) and sit-to stand test (STS). Static balance was assessed by one-legged stance test (OLST) and chronic inflammation by IL-6 and tumor necrosis factor alpha (TNF-α). Osteosarcopenia was defined as low bone mineral density (BMD) (T-score<-1) combined with low phase angle (PhA). Comparisons were run with Students T test and Man-Whitney test. Survival probabilities were estimated using the Kaplan-Meier method. Receiver operating characteristic curve was used to analyze the association of PhA with mortality and to find the best cut-point. Results: The proportion of individuals who died in a 9-year follow up was higher in individuals with Osteosarcopenia (25%) compared to without osteosarcopenia (9%) (p=0.015). Osteosarcopenia was associated with mortality (HR: 1.4; 95% CI 1.02 - 1.29; p = 0.0151). Subjects with osteosarcopenia compared to without it presented worse performance in the ISWT (514 ±19 m vs. 621 ± 16 m), 6MWT (515 ± 7 m vs. 538 ± 6 m, p< 0.05), OLST (13.5 ±10.2 s vs.16.7 ±8.3 s) and HGS (25 ± 7 Kg vs. 28 ± 9 K5); p< 0.05 for all. The cut point used to PhA was ≤ 6.07ºfor both male and female (AUC: 0.687; Sensibility: 64% and Specificity: 61% for mortality). Conclusion: Osteosarcopenia diagnosed with low phase angle combined with low BMD is highly associated with mortality. Additionally, older adults with osteosarcopenia presented worse aerobic capacity, balance and muscle strength.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalNutricion Clinica y Dietetica Hospitalaria
Issue number4
Publication statusPublished - 2023


  • functionality
  • mortality
  • older people
  • Osteosarcopenia
  • sarcopenia

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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