Clearance of levonorgestrel from the circulation following removal of NORPLANTR subdermal implants

H. B. Croxatto, S. Díaz, M. Pavez, H. Cárdenas, M. Larsson, E. D B Johansson

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

The disappearance of levonorgestrel from plasma after the removal of NORPLANTR subdermal implants was studied in 12 women who had been treated from 5.5 to 78 months. The existence of one or two half-lives for the rate of disappearance was assessed. The influence of body weight, body fat and length of treatment upon levonorgestrel clearance was studied through stepwise regression analysis. It was found that the levonorgestrel decay rate after implant removal can be entirely accounted assuming one half-life of 42 ± 16 h ( x ̄ ± SD; range 13 to 62 h). Stepwise regression analysis showed that levonorgestrel half-life is positively correlated with body weight and not significantly correlated with the length of treatment or body fat. It is concluded that, after long-term administration of levonorgestrel via subdermal implants, the major part of the steroid is cleared from plasma within 96 h and that only trace amounts are detected in the following days.

Original languageEnglish
Pages (from-to)509-523
Number of pages15
JournalContraception
Volume38
Issue number5
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology
  • Reproductive Medicine

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