Chronic ethanol administration induces tolerance to morphine and to β-endorphin responses in the rat vas deferens

Hugo Miranda, Gonzalo Bustos, Hernan Lara

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The possibility was investigated that ethanol, chronically administered, might produce changes in the opioid receptors located on the sympathetic nerves of the rat vas deferens. Administration of ethanol, 3-9 g/kg per day for six days, resulted in tolerance to the hypnotic effects induced by ethanol (4 k/kg i.p.) and pentobarbital (35 mg/kg i.p.). Ethanol administration also resulted in tolerance to the effects of morphine and β-endorphin on the muscular twitch evoked in the rat vas deferens by neuronal stimulation.. In contrast, chronic ethanol did not significantly change the effects on vas deferens contractions induced by exogenous bioamines such as noradrenaline and dopamine and by acetylcholine. These results suggest that ethanol and opioids have certain biochemical mechanisms in common which might express themselves at the level of prejunctional components involved in the modulation of neurotransmitter action in the rat vas deferens.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalEuropean Journal of Pharmacology
Volume87
Issue number2-3
DOIs
Publication statusPublished - 18 Feb 1983

Keywords

  • Ethanol
  • Opioid receptor
  • Prejunctional modulation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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