Chronic effects of oxypertine on the isolated vas deferens of the rat

H. Miranda, Daisy Naquira

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

1. Chronic pretreatment of rats with oxypertine induced the appearance of spontaneous contractions in the isolated vasa deferentia, with initial hyposensitivity but late hypersensitivity to noradrenaline, without changes in ED50 to dopamine and with enhanced maximal responses to both agonists. 2. These effects are compared to the different profiles induced by chronic pretreatment with haloperidol, imipramine and reserpine.

Original languageEnglish
Pages (from-to)325-328
Number of pages4
JournalGeneral Pharmacology
Volume9
Issue number5
DOIs
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Pharmacology

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