TY - JOUR
T1 - Chromatin remodeling during sea urchin early development
T2 - Molecular determinants for pronuclei formation and transcriptional activation
AU - Imschenetzky, María
AU - Puchi, Marcia
AU - Morín, Violeta
AU - Medina, Ricardo
AU - Montecino, Martín
N1 - Funding Information:
The authors thank Soraya Gutierrez and Roberto Paredes for the critical reading of this manuscript and interesting comments. This work has been supported by grants from FONDECYT 1000361 (to MM) and 1011073 (to MI), and from DIUC 201.031.090-1.4 (to MM).
PY - 2003/12/11
Y1 - 2003/12/11
N2 - Transcriptional activation of specific genes is initiated after fertilization by the interaction of specific transcription factors with its cognate sequences in the chromatin context, thereby leading to a concerted and coordinated program which determines early development. Remodeling of the sperm chromatin after fertilization is a fundamental event for transcriptional activation and expression of the paternally inherited genome. The transitions in chromosomal proteins, as well as the mechanisms that participate in these transitions, have been investigated only to a limited extent as compared to the signal transduction patterns that govern egg activation or the dynamics and structural changes accompanying sperm nuclear membrane dissociation-association following insemination. In this review, we will discuss the remodeling of sperm chromatin that follows fertilization. We will emphasize the transitions of chromosomal proteins, as well as the post-translational modifications associated with these transitions. The molecular mechanisms that may be participating in these events will also be analyzed. We will further discuss the mechanisms that govern chromatin remodeling and the role of specific transcription factors in the control of the transcriptional program during sea urchin early development.
AB - Transcriptional activation of specific genes is initiated after fertilization by the interaction of specific transcription factors with its cognate sequences in the chromatin context, thereby leading to a concerted and coordinated program which determines early development. Remodeling of the sperm chromatin after fertilization is a fundamental event for transcriptional activation and expression of the paternally inherited genome. The transitions in chromosomal proteins, as well as the mechanisms that participate in these transitions, have been investigated only to a limited extent as compared to the signal transduction patterns that govern egg activation or the dynamics and structural changes accompanying sperm nuclear membrane dissociation-association following insemination. In this review, we will discuss the remodeling of sperm chromatin that follows fertilization. We will emphasize the transitions of chromosomal proteins, as well as the post-translational modifications associated with these transitions. The molecular mechanisms that may be participating in these events will also be analyzed. We will further discuss the mechanisms that govern chromatin remodeling and the role of specific transcription factors in the control of the transcriptional program during sea urchin early development.
KW - Chromatin remodeling
KW - Fertilization
KW - Sea urchins
UR - http://www.scopus.com/inward/record.url?scp=0345303844&partnerID=8YFLogxK
U2 - 10.1016/j.gene.2003.08.024
DO - 10.1016/j.gene.2003.08.024
M3 - Review article
C2 - 14644495
AN - SCOPUS:0345303844
SN - 0378-1119
VL - 322
SP - 33
EP - 46
JO - Gene
JF - Gene
IS - 1-2
ER -