Central odontogenic fibroma: an international multicentric study of 62 cases

Ana Luiza Oliveira Corrêa Roza, Emanuel Mendes Sousa, Amanda Almeida Leite, Gleyson Kleber Amaral-Silva, Thayná Melo de Lima Morais, Vivian Petersen Wagner, Lauren Frenzel Schuch, Ana Carolina Uchoa Vasconcelos, José Alcides Almeida de Arruda, Ricardo Alves Mesquita, Felipe Paiva Fonseca, Aline Corrêa Abrahão, Michelle Agostini, Bruno Augusto Benevenuto de Andrade, Ericka Janine Dantas da Silveira, René Martínez-Flores, Benjamin Martínez Rondanelli, Javier Alberdi-Navarro, Liam Robinson, Constanza MarinJosé Narciso Rosa Assunção Júnior, Renato Valiati, Eduardo Rodrigues Fregnani, Alan Roger Santos-Silva, Marcio Ajudarte Lopes, Keith D. Hunter, Syed Ali Khurram, Paul M. Speight, Adalberto Mosqueda-Taylor, Willie F.P. van Heerden, Román Carlos, John M. Wright, Oslei Paes de Almeida, Mário José Romañach, Pablo Agustin Vargas

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Objective: The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF). Study Design: Clinical and radiographic data were collected from the records of 13 oral pathology laboratories. All cases were microscopically reviewed, considering the current World Health Organization classification of tumors and were classified according to histopathologic features. Results: There were 43 females and 19 males (average age 33.9 years; range 8–63 years). Clinically, COdF lesions appeared as asymptomatic swellings, occurring similarly in the maxilla (n = 33) and the mandible (n = 29); 9 cases exhibited palatal depression. Imaging revealed well-defined, interradicular unilocular (n = 27), and multilocular (n = 12) radiolucencies, with displacement of contiguous teeth (55%) and root resorption (46.4%). Microscopically, classic features of epithelial-rich (n = 33), amyloid (n = 10), associated giant cell lesion (n = 7), ossifying (n = 6), epithelial-poor (n = 3), and granular cell (n = 3) variants were seen. Langerhans cells were highlighted by CD1a staining in 17 cases. Most patients underwent conservative surgical treatments, with 1 patient experiencing recurrence. Conclusions: To the best of our knowledge, this study represents the largest clinicopathologic study of COdF. Most cases appeared as locally aggressive lesions located in tooth-bearing areas in middle-aged women. Inactive-appearing odontogenic epithelium is usually observed within a fibrous/fibromyxoid stroma, occasionally exhibiting amyloid deposits, multinucleated giant cells, or granular cells.

Original languageEnglish
Pages (from-to)549-557
Number of pages9
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Issue number5
Publication statusAccepted/In press - 2020

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging


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