Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor

Andres Gonzalez, Guillermo Moya-Alvarado, Christian Gonzalez-Billaut, Francisca C. Bronfman

Research output: Contribution to journalReview articlepeer-review

48 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms underlying this process are not fully understood. In recent years, several advances have shed new light on the processes behind the regulation of BDNF-mediated structural plasticity including control of neuronal transcription, local translation of proteins, and regulation of cytoskeleton and membrane dynamics. In this review, we summarize recent advances in the field of BDNF signaling in neurons to induce neuronal growth.

Original languageEnglish
Pages (from-to)612-628
Number of pages17
JournalCytoskeleton
Volume73
Issue number10
DOIs
Publication statusPublished - 1 Oct 2016
Externally publishedYes

Keywords

  • BDNF
  • cytoskeleton dynamics
  • dendritic growth
  • membrane trafficking
  • signaling

ASJC Scopus subject areas

  • Structural Biology
  • Cell Biology

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