Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor

Andres Gonzalez; Guillermo Moya-Alvarado; Christian Gonzalez-Billaut; Francisca C. Bronfman

doi:10.1002/cm.21312

Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor

Andres Gonzalez, Guillermo Moya-Alvarado, Christian Gonzalez-Billaut, Francisca C. Bronfman

Research output: Contribution to journal › Review article › peer-review

111 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms underlying this process are not fully understood. In recent years, several advances have shed new light on the processes behind the regulation of BDNF-mediated structural plasticity including control of neuronal transcription, local translation of proteins, and regulation of cytoskeleton and membrane dynamics. In this review, we summarize recent advances in the field of BDNF signaling in neurons to induce neuronal growth.

Original language	English
Pages (from-to)	612-628
Number of pages	17
Journal	Cytoskeleton
Volume	73
Issue number	10
DOIs	https://doi.org/10.1002/cm.21312
Publication status	Published - 1 Oct 2016
Externally published	Yes

Keywords

BDNF
cytoskeleton dynamics
dendritic growth
membrane trafficking
signaling

ASJC Scopus subject areas

Structural Biology
Cell Biology

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10.1002/cm.21312

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abstract = "Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms underlying this process are not fully understood. In recent years, several advances have shed new light on the processes behind the regulation of BDNF-mediated structural plasticity including control of neuronal transcription, local translation of proteins, and regulation of cytoskeleton and membrane dynamics. In this review, we summarize recent advances in the field of BDNF signaling in neurons to induce neuronal growth.",

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AU - Gonzalez, Andres

AU - Moya-Alvarado, Guillermo

AU - Gonzalez-Billaut, Christian

AU - Bronfman, Francisca C.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms underlying this process are not fully understood. In recent years, several advances have shed new light on the processes behind the regulation of BDNF-mediated structural plasticity including control of neuronal transcription, local translation of proteins, and regulation of cytoskeleton and membrane dynamics. In this review, we summarize recent advances in the field of BDNF signaling in neurons to induce neuronal growth.

AB - Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms underlying this process are not fully understood. In recent years, several advances have shed new light on the processes behind the regulation of BDNF-mediated structural plasticity including control of neuronal transcription, local translation of proteins, and regulation of cytoskeleton and membrane dynamics. In this review, we summarize recent advances in the field of BDNF signaling in neurons to induce neuronal growth.

KW - BDNF

KW - cytoskeleton dynamics

KW - dendritic growth

KW - membrane trafficking

KW - signaling

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DO - 10.1002/cm.21312

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EP - 628

JO - Cytoskeleton

JF - Cytoskeleton

IS - 10

ER -

Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor

Abstract

Keywords

ASJC Scopus subject areas

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