Bromodomains in living cells participate in deciphering the histone code

Alejandra Loyola, Genevieve Almouzni

Research output: Contribution to journalShort surveypeer-review

30 Citations (Scopus)

Abstract

The bromodomain, a module of ∼110 amino acids, is found in several chromatin-associated proteins, including histone acetyltransferases and chromatin-remodeling factors, and can bind to acetylated lysines. Such post-translational modifications occur mainly in the N-terminal tail of the histone proteins and, in combination with other modifications, are thought to participate in defining a histone code. Recent findings provide a model for how bromodomain-containing proteins participate in the recognition of acetylated histones.

Original languageEnglish
Pages (from-to)279-281
Number of pages3
JournalTrends in Cell Biology
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 2004

ASJC Scopus subject areas

  • Cell Biology

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