TY - JOUR
T1 - Bromodomains in living cells participate in deciphering the histone code
AU - Loyola, Alejandra
AU - Almouzni, Genevieve
N1 - Funding Information:
We thank Andreas Ladurner, Edith Heard and Patricia Le-Baccon for insightful comments. A.L. was supported by an Institut Curie fellowship and then an EMBO fellowship (ALTF 635-2003). G.A.'s team is supported by a collaborative program between the Curie Institute and the Commissariat à l'Energie Atomique (PIC Paramètres Epigénétiques); la Ligue Nationale contre le Cancer (Equipe labellisée la Ligue); Euratom (FIGH-CT-1999–00010 and FIGH-CT-2002–00207); the Commissariat à l'Energie Atomique (LRC no. 26); and European Contracts RTN (HPRN-CT-2000–00078 and HPRN-CT-2002–00238).
PY - 2004/6
Y1 - 2004/6
N2 - The bromodomain, a module of ∼110 amino acids, is found in several chromatin-associated proteins, including histone acetyltransferases and chromatin-remodeling factors, and can bind to acetylated lysines. Such post-translational modifications occur mainly in the N-terminal tail of the histone proteins and, in combination with other modifications, are thought to participate in defining a histone code. Recent findings provide a model for how bromodomain-containing proteins participate in the recognition of acetylated histones.
AB - The bromodomain, a module of ∼110 amino acids, is found in several chromatin-associated proteins, including histone acetyltransferases and chromatin-remodeling factors, and can bind to acetylated lysines. Such post-translational modifications occur mainly in the N-terminal tail of the histone proteins and, in combination with other modifications, are thought to participate in defining a histone code. Recent findings provide a model for how bromodomain-containing proteins participate in the recognition of acetylated histones.
UR - http://www.scopus.com/inward/record.url?scp=2942709639&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2004.04.005
DO - 10.1016/j.tcb.2004.04.005
M3 - Short survey
C2 - 15183183
AN - SCOPUS:2942709639
SN - 0962-8924
VL - 14
SP - 279
EP - 281
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 6
ER -