TY - JOUR
T1 - Bookmarking target genes in mitosis
T2 - A shared epigenetic trait of phenotypic transcription factors and oncogenes?
AU - Zaidi, Sayyed K.
AU - Grandy, Rodrigo A.
AU - Lopez-Camacho, Cesar
AU - Montecino, Martin
AU - Van Wijnen, Andre J.
AU - Lian, Jane B.
AU - Stein, Janet L.
AU - Stein, Gary S.
PY - 2014/1/15
Y1 - 2014/1/15
N2 - The regulatory information for phenotype, proliferation, and growth of normal and tumor cells must be maintained through genome replication in the S phase and cell division during mitosis. Epigenetic mechanisms that include DNA methylation, posttranslational modifications of histones, selective utilization of histone variants, and inheritable RNA molecules play pivotal roles in maintaining cellular identity through mitotic divisions. Recent studies demonstrate that mitotic occupancy of genes, which are determinants of cell fate, growth, and proliferation, by lineage-restricted transcription factors is a key epigenetic mechanism for retention and transmission of cellular expression memory. Evidence is emerging for the presence of distinct transcriptional regulatory microenvironments in mitotic chromosomes in which the genes bookmarked for reactivation postmitotically reside. Importantly, some oncoproteins are present in mitotic microenvironments where they occupy target genes during mitosis and may contribute to perpetuating the transformed phenotype. We discuss emerging regulatory implications of epigenetically bookmarking genes during mitosis for physiologic control as well as for the onset and progression of cancer.
AB - The regulatory information for phenotype, proliferation, and growth of normal and tumor cells must be maintained through genome replication in the S phase and cell division during mitosis. Epigenetic mechanisms that include DNA methylation, posttranslational modifications of histones, selective utilization of histone variants, and inheritable RNA molecules play pivotal roles in maintaining cellular identity through mitotic divisions. Recent studies demonstrate that mitotic occupancy of genes, which are determinants of cell fate, growth, and proliferation, by lineage-restricted transcription factors is a key epigenetic mechanism for retention and transmission of cellular expression memory. Evidence is emerging for the presence of distinct transcriptional regulatory microenvironments in mitotic chromosomes in which the genes bookmarked for reactivation postmitotically reside. Importantly, some oncoproteins are present in mitotic microenvironments where they occupy target genes during mitosis and may contribute to perpetuating the transformed phenotype. We discuss emerging regulatory implications of epigenetically bookmarking genes during mitosis for physiologic control as well as for the onset and progression of cancer.
UR - http://www.scopus.com/inward/record.url?scp=84892924886&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-13-2837
DO - 10.1158/0008-5472.CAN-13-2837
M3 - Review article
C2 - 24408924
AN - SCOPUS:84892924886
SN - 0008-5472
VL - 74
SP - 420
EP - 425
JO - Cancer Research
JF - Cancer Research
IS - 2
ER -