Biosynthetic human EGF accelerates healing of Neodecadron-treated primate corneas

J. R. Brightwell, S. L. Riddle, R. A. Eiferman, P. Valenzuela, P. J. Barr, J. P. Merryweather, G. S. Schultz

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

Topical administration of biosynthetic human epidermal growth factor (h-EGF), given in combination with an antibiotic and synthetic steroid (Neodecadron) accelerated the rate of corneal epithelial regeneration and significantly increased the strength of full-thickness stromal incisions in primates. The regenerated epithelial cells of EGF-Neodecadron-treated corneas appeared normal on histologic examination and showed no evidence of hypertrophy or hyperplasia. The EGF-Neodecadron-treated stromal incisions were characterized by new collagen formation and a smaller epithelial cell plug than Neodecadron-treated control corneas. These results suggest that biosynthetic h-EGF, which lacks the immunologic potential of nonhuman proteins, may be effective in accelerating healing of corneal epithelial defects and stromal incisions in patients whose healing is suppressed by treatment with steroids.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume26
Issue number1
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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