Biopesticide activity from drimanic compounds to control tomato pathogens

Iván Montenegro, Alejandro Madrid, Mauricio Cuellar, Michael Seeger, Juan Felipe Alfaro, Ximena Besoain, Juan Pablo Martínez, Ingrid Ramirez, Yusser Olguín, Miryam Valenzuela

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Tomato crops can be affected by several infectious diseases produced by bacteria, fungi, and oomycetes. Four phytopathogens are of special concern because of the major economic losses they generate worldwide in tomato production; Clavibacter michiganensis subsp. michiganensis and Pseudomonas syringae pv. tomato, causative agents behind two highly destructive diseases, bacterial canker and bacterial speck, respectively; fungus Fusarium oxysporum f. sp. lycopersici that causes Fusarium Wilt, which strongly affects tomato crops; and finally, Phytophthora spp., which affect both potato and tomato crops. Polygodial (1), drimenol (2), isonordrimenone (3), and nordrimenone (4) were studied against these four phytopathogenic microorganisms. Among them, compound 1, obtained from Drimys winteri Forst, and synthetic compound 4 are shown here to have potent activity. Most promisingly, the results showed that compounds 1 and 4 affect Clavibacter michiganensis growth at minimal inhibitory concentrations (MIC) values of 16 and 32 μg/mL, respectively, and high antimycotic activity against Fusarium oxysporum and Phytophthora spp. with MIC of 64 μg/mL. The results of the present study suggest novel treatment alternatives with drimane compounds against bacterial and fungal plant pathogens.

Original languageEnglish
Article number2053
Issue number8
Publication statusPublished - 16 Aug 2018


  • Clavibacter michiganensis
  • Drimenol
  • Fusarium oxysporum
  • Isonordrimenone
  • Phytophthora
  • Polygodial
  • Pseudomonas syringae pv. tomato

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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