Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?

Daniel Peña-Oyarzun, Roberto Bravo-Sagua, Alexis Diaz-Vega, Larissa Aleman, Mario Chiong, Lorena Garcia, Claudia Bambs, Rodrigo Troncoso, Mariana Cifuentes, Eugenia Morselli, Catterina Ferreccio, Andrew F.G. Quest, Alfredo Criollo, Sergio Lavandero

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)

Abstract

Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; however they share common features, which are critical for the development of novel therapeutic strategies. A persistently altered inflammatory response is typically observed in many NCDs together with redox imbalance. Additionally, dysregulated proteostasis, mainly derived as a consequence of compromised autophagy, is a common feature of several chronic diseases. In this review, we discuss the crosstalk among inflammation, autophagy and oxidative stress, and how they participate in the progression of chronic diseases such as cancer, cardiovascular diseases, obesity and type II diabetes mellitus.

Original languageEnglish
Pages (from-to)61-78
Number of pages18
JournalFree Radical Biology and Medicine
Volume124
DOIs
Publication statusPublished - 20 Aug 2018

Keywords

  • Autophagy
  • Cancer
  • Cardiovascular diseases
  • Diabetes mellitus
  • Inflammation
  • Non-communicable diseases
  • Obesity
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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