TY - JOUR
T1 - Autophagy and oxidative stress in non-communicable diseases
T2 - A matter of the inflammatory state?
AU - Peña-Oyarzun, Daniel
AU - Bravo-Sagua, Roberto
AU - Diaz-Vega, Alexis
AU - Aleman, Larissa
AU - Chiong, Mario
AU - Garcia, Lorena
AU - Bambs, Claudia
AU - Troncoso, Rodrigo
AU - Cifuentes, Mariana
AU - Morselli, Eugenia
AU - Ferreccio, Catterina
AU - Quest, Andrew F.G.
AU - Criollo, Alfredo
AU - Lavandero, Sergio
N1 - Funding Information:
This work was kindly supported by grants from Fondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT ( 1171075 to AC, 1160820 to EM, 1150651 to MC, 1161156 to SL and 1140713 to LG); by PIA ( ACT172066 to RT, EM and AC), FONDAP ( 15130011 to MCh, LG, CB, CF, RT, AQ, AC and SL), Convocatoria Nacional de Subvención a Instalación en la Academia ( 77170004 to RBS), Postdoctoral project ( 3160226 to RBS), Ph.D. Fellowships Program ( 21140458 to D.P-O) from the Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) and by the International Centre for Genetic Engineering and Biotechnology, ICGEB , ( CRP/CHL16-06 to EM)
PY - 2018/8/20
Y1 - 2018/8/20
N2 - Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; however they share common features, which are critical for the development of novel therapeutic strategies. A persistently altered inflammatory response is typically observed in many NCDs together with redox imbalance. Additionally, dysregulated proteostasis, mainly derived as a consequence of compromised autophagy, is a common feature of several chronic diseases. In this review, we discuss the crosstalk among inflammation, autophagy and oxidative stress, and how they participate in the progression of chronic diseases such as cancer, cardiovascular diseases, obesity and type II diabetes mellitus.
AB - Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; however they share common features, which are critical for the development of novel therapeutic strategies. A persistently altered inflammatory response is typically observed in many NCDs together with redox imbalance. Additionally, dysregulated proteostasis, mainly derived as a consequence of compromised autophagy, is a common feature of several chronic diseases. In this review, we discuss the crosstalk among inflammation, autophagy and oxidative stress, and how they participate in the progression of chronic diseases such as cancer, cardiovascular diseases, obesity and type II diabetes mellitus.
KW - Autophagy
KW - Cancer
KW - Cardiovascular diseases
KW - Diabetes mellitus
KW - Inflammation
KW - Non-communicable diseases
KW - Obesity
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85048021398&partnerID=8YFLogxK
U2 - 10.1016/j.freeradbiomed.2018.05.084
DO - 10.1016/j.freeradbiomed.2018.05.084
M3 - Review article
AN - SCOPUS:85048021398
SN - 0891-5849
VL - 124
SP - 61
EP - 78
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
ER -
