The theoretical study of both the conformational distribution and the acid cyclization of two epimeric 5-oxogermacren-6,12-olides in C4 is described. Our results on the stereochemistry of the cyclization products, 5-hydroxyguaian-6,12-olides, agree with experimental results reported previously. Curtin-Hammetprinciple and Hammondpostulate are used to propose reaction pathways consistent with above results.The theoretical results were obtained by using a MM2 program from HyperChem 4.5.
|Number of pages||9|
|Journal||Boletin de la Sociedad Chilena de Quimica|
|Publication status||Published - 2001|
- Mm2 program
- Sesquiterpenic lactones
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