Association of Sitting Time With All-Cause and Cardiovascular Mortality: How Does Frailty Modify This Association?

Felipe Diaz-Toro, Carolina Nazzal Nazal, Gabriela Nazar, Ximena Diaz-Martinez, Yeny Concha-Cisternas, Carlos Celis-Morales, Fanny Petermann-Rocha

Research output: Contribution to journalArticlepeer-review


To investigate how frailty modifies the association of sitting time with all-cause and cardiovascular mortality in Chilean adults. This prospective study included 2,604 participants aged ≥35 from the Chilean National Health Survey 2009–2010. Sitting time was self-reported, while frailty was assessed using a 36-item Frailty Index. Sitting time was categorized as low, medium, and high. Cox proportional hazard models were used to estimate the risk of mortality stratified for the sitting time categories. Over a median follow-up of 8.9 years, 311 participants died, 28% of them due to cardiovascular events. Frail people with prolonged sitting time were at higher risk of all-cause and cardiovascular mortality (hazard ratio 3.13; 95% confidence interval [2.06, 4.71] and hazard ratio 2.41; 95% confidence interval [1.50, 3.64], respectively). The observed risk was higher in women than men. Public health and individual strategies should be implemented to decrease sitting time across the population, with special attention on frail people.

Original languageEnglish
Pages (from-to)236-243
Number of pages8
JournalJournal of Aging and Physical Activity
Issue number2
Publication statusPublished - Apr 2024


  • Chile
  • frail
  • sedentary behaviors

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Gerontology
  • Geriatrics and Gerontology


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