Aortic pulse wave analysis and functional capacity of heart transplantation candidates: a pilot study

Adriana Marques Alcici-Moreira, Marcela Oliveira Vitarelli, Tiago Abreu Velloso, Igor Antônio Carvalho-Ribeiro, Daniella Moura Dario, Janaine Cunha Polese, Hélio Penna Guimarães, José Luiz Barros Pena, Marcelo Tuesta, Bruno Almeida de Rezende, Maria da Glória Rodrigues-Machado

Research output: Contribution to journalArticlepeer-review

Abstract

We compared cardiovascular parameters obtained with the Mobil-O-Graph and functional capacity assessed by the Duke Activity Status Index (DASI) before and after Heart Transplantation (HT) and also compared the cardiovascular parameters and the functional capacity of candidates for HT with a control group. Peripheral and central vascular pressures increased after surgery. Similar results were observed in cardiac output and pulse wave velocity. The significant increase in left ventricular ejection fraction (LVEF) postoperatively was not followed by an increase in the functional capacity. 24 candidates for HT and 24 controls were also compared. Functional capacity was significantly lower in the HT candidates compared to controls. Stroke volume, systolic, diastolic, and pulse pressure measured peripherally and centrally were lower in the HT candidates when compared to controls. Despite the significant increase in peripheral and central blood pressures after surgery, the patients were normotensive. The 143.85% increase in LVEF in the postoperative period was not able to positively affect functional capacity. Furthermore, the lower values of LVEF, systolic volume, central and peripheral arterial pressures in the candidates for HT are consistent with the characteristics signs of advanced heart failure, negatively impacting functional capacity, as observed by the lower DASI score.

Original languageEnglish
Article number10504
JournalScientific Reports
Volume14
Issue number1
DOIs
Publication statusPublished - Dec 2024

Keywords

  • Heart failure
  • Heart transplantation
  • Metabolic equivalent
  • Pulse wave analysis
  • Vascular stiffness

ASJC Scopus subject areas

  • General

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