Antinociceptive effects of Ca2+ channel blockers

Hugo F. Miranda, Diego Bustamante, Veronica Kramer, Teresa Pelissier, Hernan Saavedra, Carlos Paeile, Edgar Fernandez, Gianni Pinardi

Research output: Contribution to journalArticlepeer-review

126 Citations (Scopus)

Abstract

The antinociceptive action of four Ca2+ channel blockers, nifedipine, nimodipine, verapamil and diltiazem, was evaluated and compared to that of morphine using three algesiometric tests in mice and rats, namely, formalin, writhing and modified hot-plate test. Dose-response curves for all the drugs tested were similar and a significant dose-dependent antinociceptive action was evident in the formalin and writhing tests. However, in the hot-plate test, only nimodipine exhibited a significant analgesic effect, confirming the misleading results previously reported for this test. The findings suggest a pharmacological role of Ca2+ channel blockers in the modulation of antinociception under acute conditions. The analgesic action of Ca2+ channel blockers could be mediated by an increase in the nociceptive threshold resulting from interference with Ca2+ influx at opioid receptors, because Ca2+ influx is critical for the release of neurotransmitters and other substances implicated in nociception and inflammation. It is suggested that if a substance has a Ca2+ channel blocking effect, it should probably have some antinociceptive properties.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalEuropean Journal of Pharmacology
Volume217
Issue number2-3
DOIs
Publication statusPublished - 7 Jul 1992

Keywords

  • Antinociception
  • Ca channel blockers
  • Formalis test
  • Hot-plate test
  • Writhing test

ASJC Scopus subject areas

  • Pharmacology

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